Factors associated with mortality among moderate and severe patients with COVID-19 in India: a secondary analysis of a randomised controlled trial.
Joy John Mammen,Snehil Kumar,Lovely Thomas,Gunjan Kumar,Anand Zachariah,Lakshmanan Jeyaseelan,John Victor Peter,Anup Agarwal,Aparna Mukherjee,Pranab Chatterjee,Tarun Bhatnagar,Jess Elizabeth Rasalam,Binila Chacko,Thenmozhi Mani,Melvin Joy,Priscilla Rupali,Malathi Murugesan,Dolly Daniel,B Latha,Sunita Bundas,Vivek Kumar,Ravi Dosi,Janakkumar R Khambholja,Rosemarie de Souza,B Thrilok Chander,Shalini Bahadur,Simmi Dube,Amit Suri,Aikaj Jindal,Om Shrivastav,Vijay Barge,Archana Bajpayee,Pankaj Malhotra,Neha Singh,Muralidhar Tambe,Nimisha Sharma,Shreepad Bhat,Ram S Kaulgud,Anil Gurtoo,D. Himanshu Reddy,Kamlesh Upadhyay,Ashish Jain,Tinkal C Patel,Irfan Nagori,Pramod R Jha,KV Sreedhar Babu,C Aparna,Sunil J Panjwani,M Natarajan,Milind Baldi,Vrushali Khirid Khadke,Seema Dua,Ravindraa Singh,Ashish Sharma,Jayashree Sharma,Yojana A Gokhale,Pragya D Yadav,Gajanan N. Sapkal,Himanshu Kaushal,V Saravana Kumar +59 more
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In this article, the authors analyzed the factors associated with mortality in a cohort of moderately and severely ill patients with COVID-19 enrolled in a randomised trial on convalescent plasma.Abstract:
Objective Large data on the clinical characteristics and outcome of COVID-19 in the Indian population are scarce. We analysed the factors associated with mortality in a cohort of moderately and severely ill patients with COVID-19 enrolled in a randomised trial on convalescent plasma. Design Secondary analysis of data from a Phase II, Open Label, Randomized Controlled Trial to Assess the Safety and Efficacy of Convalescent Plasma to Limit COVID-19 Associated Complications in Moderate Disease. Setting 39 public and private hospitals across India during the study period from 22 April to 14 July 2020. Participants Of the 464 patients recruited, two were lost to follow-up, nine withdrew consent and two patients did not receive the intervention after randomisation. The cohort of 451 participants with known outcome at 28 days was analysed. Primary outcome measure Factors associated with all-cause mortality at 28 days after enrolment. Results The mean (SD) age was 51±12.4 years; 76.7% were males. Admission Sequential Organ Failure Assessment score was 2.4±1.1. Non-invasive ventilation, invasive ventilation and vasopressor therapy were required in 98.9%, 8.4% and 4.0%, respectively. The 28-day mortality was 14.4%. Median time from symptom onset to hospital admission was similar in survivors (4 days; IQR 3–7) and non-survivors (4 days; IQR 3–6). Patients with two or more comorbidities had 2.25 (95% CI 1.18 to 4.29, p=0.014) times risk of death. When compared with survivors, admission interleukin-6 levels were higher (p 10 (9.97, 3.65–27.13, p 1.0 mg/L (2.50, 1.14–5.48, p=0.022), ferritin ≥500 ng/mL (2.67, 1.44–4.96, p=0.002) and lactate dehydrogenase ≥450 IU/L (2.96, 1.60–5.45, p=0.001) were significantly associated with death. Conclusion In this cohort of moderately and severely ill patients with COVID-19, severity of illness, underlying comorbidities and elevated levels of inflammatory markers were significantly associated with death. Trial registration number CTRI/2020/04/024775.read more
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“Vaccination saves lives: a real-time study of patients with chronic diseases and severe COVID-19 infection”
Aparna Mukherjee,Gunjan Kumar,Alka Turuk,Ashish Bhalla,Thrilok Chander Bingi,Pankaj Bhardwaj,Tridip Dutta Baruah,Subhasis Mukherjee,Arunansu Talukdar,Yogiraj Ray,Mary John,Janak R. Khambholja,A. Patel,Sourin Bhuniya,Rajnish Joshi,Geetha R Menon,Damodar Sahu,Vishnu Vardhan Rao,Balram Bhargava,Samiran Panda,P. Mishra,Yashmin Panchal,Lokesh Kumar Sharma,Anup Agarwal,Goverdhan Dutt Puri,Vikas Suri,Karan Singla,Raja Rao Mesipogu,Vinaya Sekhar Aedula,Mohammed Ayaz Mohiuddin,Deepak Kumar,Suman Saurabh,Sarthak Misra,Pankaj Kannauje,Amit Kumar,Arvind Kumar Shukla,Amit Achyut Pal,Shreetama Chakraborty,Moumita Dutta,Tanushree Mondal,Sarmistha Chakravorty,Boudhyan Bhattacharjee,S. R. Paul,Debojyoti Basu Majumder,Subhranga Chatterjee,Abi Abraham,Divya Varghese,Mari Thomas,Nitesh Shah,M. Patel,Surabhi Madan,Anita Desai,Kala Yadhav M L,M. R.,Chetna G S,Umesh Kumar Ojha,Ravi Ranjan Jha,Avinash Kumar,Ashish Pathak,Ashish Sharma,Manju Raj Purohit,Lisa Sarangi,M Rath,Arti Shah,Lavlesh Kumar,Princee Patel,Naveen Dulhani,Simmi Dube,Jyotsna Shrivastava,Arvind Mittal,Lipilekha Patnaik,Jagdish Prasad Sahoo,Sumita Sharma,V.K. Katyal,Ashima Katyal,Nidhi Yadav,R. Upadhyay,S. K. Srivastava,Anurag Srivastava,Nilay N Suthar,Nehaly Shah,Kruti Rajvansh,Hemang Purohit,Prasanta K. Mohapatra,Manoj Kumar Panigrahi,Saurabh Saigal,Alkesh Kumar Khurana,Manisha Panchal,Mayank Anderpa,D S Patel,Veeresh B. Salgar,Santosh Algur,Ratnamala Choudhury,Mangala Rao,N. D,B. K. Gupta,B. Mahendra Kumar,Jigyasa Gupta,Sudhir Bhandari,Abhishek Agrawal,Mohammad Shameem,Nazish Fatima,Star Pala,Vijay Noel Nongpiur,S. Chatterji,Sudipta Mukherjee,Sachin K. Shivnitwar,Srikanth Tripathy,Prajakta Lokhande,Himanshu Dandu,Amit Gupta,Vivek Kumar,Nikita Sharma,R. M. Vohra,Archana Paliwal,M. P. Kumar,Asbwini Rao,Nyanthung Kikon,Rhondemo Kikon,Kamal Manohar,Y. S. N. Raju,Arun Madharia,Jaya Chakravarty,Manaswi Chaubey,Rajiv Bandaru,M. Mirza,Sushila Kataria,Pooja Sharma,Soumitra Ghosh,Avijit Hazra +129 more
TL;DR: WHO ordinal scale at admission is the most important independent predictor for in-hospital death in COVID-19 patients and anti-SARS-CoV2 vaccination provides significant protection against mortality.
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Biomarkers and Outcomes in Hospitalized Covid-19 Patients: A Prospective Registry
R.S. Khedar,S. K. Sharma,Kriti Mittal,H. C. Ambaliya,Jugal Bihari Gupta,S. Singh,Yogendra Singh,A Mathur +7 more
TL;DR: In Covid-19, high levels of biomarkers- hsCRP, D-dimer, IL-6, LDH, ferritin and NLR are associated with more severe illness and significantly greater in-hospital mortality.
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Association of vasopressors with mortality in critically ill patients with COVID-19: a systematic review and meta-analysis
Maria Mermiri,Georgios Mavrovounis,Eleni Laou,Nikolaos Papagiannakis,Ioannis Panagopoulos,Athanasios Chalkias +5 more
TL;DR: In this article , the effect of vasopressors on mortality of critically ill patients with coronavirus disease 2019 (COVID-19) was investigated using a systematic search of PubMed, Scopus, and ClinicalTrials.gov until December 2022.
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Blood phenotype O and indirect bilirubin are associated with lower, early COVID-19—related mortality: A retrospective study
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Biomarkers and outcomes in hospitalised patients with COVID-19: a prospective registry
R.S. Khedar,Rajeev Gupta,Krishna K. Sharma,Kartik Mittal,H. C. Ambaliya,Jugal Bihari Gupta,Surendra Singh,Yogendra Singh,Alok Mathur +8 more
TL;DR: In this paper , the authors determined association of biomarkers (hsCRP, D-dimer, interleukin-6 (IL-6), lactic dehydrogenase (LDH), ferritin and neutrophil-lymphocyte ratio (NLR) at hospitalisation with outcomes in COVID-19.
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