Failure of cytotoxic drugs to suppress immune responses of patients with rheumatoid arthritis.
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TLDR
Whether cytotoxic drugs do indeed suppress the immune response of patients with rheumatoid arthritis and to determine whether any such immunosuppression can be correlated with clinical improvement is asked.Abstract:
Cytotoxic drugs suppress many forms of immune and inflammatory response in animals (Gabrielsen and Good, 1967). It has been argued that their immunosuppressive properties justify the use of these drugs in the treatment of putative autoimmune diseases in man. As a result they have been used to treat chronic inflammatory diseases including rheumatoid arthritis (Mason, Currey, Barnes, Dunne, Hazleman, and Strickland, 1969). It is pertinent to ask, however, whether cytotoxic drugs do indeed suppress the immune response of patients with rheumatoid arthritis and to determine whether any such immunosuppression can be correlated with clinical improvement.read more
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Journal ArticleDOI
EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases
S. van Assen,Nancy Agmon-Levin,Ori Elkayam,Ricard Cervera,Michele F. Doran,Maxime Dougados,Paul Emery,Paul Emery,Pierre Geborek,John P. A. Ioannidis,David Jayne,Cees G. M. Kallenberg,Ulf Müller-Ladner,Yehuda Shoenfeld,Yehuda Shoenfeld,Ljudmila Stojanovich,Guido Valesini,NM Wulffraat,Marc Bijl +18 more
TL;DR: Recommendations for vaccination in patients with AIIRD based on the currently available evidence and expert opinion were formulated, and more research is needed, particularly regarding the incidence of vaccine-preventable infectious diseases and the safety of vaccination in Patients with A IIRD.
Journal ArticleDOI
2019 update of EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases
Victoria Furer,Victoria Furer,Christien Rondaan,Marloes W Heijstek,Nancy Agmon-Levin,Nancy Agmon-Levin,Sander van Assen,Marc Bijl,F. C. Breedveld,Raffaele D'Amelio,Maxime Dougados,Meliha C Kapetanovic,Jacob M van Laar,A. De Thurah,Robert Landewé,Anna Molto,Ulf Müller-Ladner,Karen Schreiber,Leo Smolar,James T. Walker,Klaus Warnatz,Nico M Wulffraat,Ori Elkayam,Ori Elkayam +23 more
TL;DR: The updated EULAR recommendations provide an up-to-date guidance on the management of vaccinations in patients with AIIRD, favouring vaccination during quiescent disease, preferably prior to the initiation of immunosuppression.
Book ChapterDOI
Immunodepression and malignancy.
TL;DR: Both clinical and experimental evidence indicates that the diseases or procedures that lower the immune functions in mammals are associated with a higher incidence of malignancies.
Journal ArticleDOI
EULAR recommendations for vaccination in paediatric patients with rheumatic diseases
Marloes W Heijstek,L. M. Ott de Bruin,Marc Bijl,R. Borrow,F. van der Klis,Isabelle Koné-Paut,Anders Fasth,Kirsten Minden,Angelo Ravelli,Mario Abinun,Gecilmara Salviato Pileggi,Michael Borte,NM Wulffraat +12 more
TL;DR: More research is needed on the safety and immunogenicity of (live-attenuated) vaccination in PaedRD, particularly in those using biologicals, and the effect of vaccination on prevention of infections.
Journal ArticleDOI
Cytotoxic Drugs in Treatment of Nonmalignant Diseases
Alfred D. Steinberg,Paul H. Plotz,Sheldon M. Wolff,Vernon G. Wong,Saul G. Agus,John L. Decker +5 more
TL;DR: The basis for using cytotoxic drugs in inflammatory diseases of uncertain cause is their immunosuppressive properties, and these drugs interrupt nucleic acid and protein synthesis, thereby halting their activity in these diseases.
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