Journal ArticleDOI
Familial Study of Hirsutism
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A significant familial aggregation of hirsutism was found and propositi with their relatives set the basis for a genetic etiology, a multifactorial pattern of inheritance being a plausible one.Abstract:
The familial incidence and distribution of hirsutism and other related symptoms have been ascertained in 90 females ranging in age from 15 to 45, in their first degree relatives (mothers and sisters), and in a control group. On clinical grounds, patients were placed in 3 categories: ovarian, adrenal and “idiopathic” hirsutism. A method was elaborated for semiquantitative estimation of the occurrence of “unusual” body hair for women and of symptoms of endocrine dysfunction. The pattern of distribution of hirsutism resembles that of a continuous one, suggesting a gradient trait ranging from the normal female to the abnormally hirsute. A significant familial aggregation of hirsutism was found and propositi with their relatives constituted a different population than controls in regard to hirsutism. This result along with the intermediacy of scores in relatives set the basis for a genetic etiology, a multifactorial pattern of inheritance being a plausible one. In hirsute women an association with var...read more
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Journal ArticleDOI
Prevalence of the polycystic ovary syndrome in unselected Black and White women of the Southeastern United States : A prospective study
Eric S. Knochenhauer,Timothy J. Key,Melissa Kahsar-Miller,W. Waggoner,Larry R. Boots,Ricardo Azziz +5 more
TL;DR: In a consecutive population of unselected women the prevalence of hirsutism varied from 2-8% depending on the chosen cut-off F-G score, with no significant difference between White and Black women.
Journal ArticleDOI
The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report
Ricardo Azziz,Enrico Carmina,Didier Dewailly,Evanthia Diamanti-Kandarakis,Héctor F. Escobar-Morreale,Walter Futterweit,Onno E. Janssen,Richard S. Legro,Robert J. Norman,Ann Taylor,Selma F. Witchel +10 more
TL;DR: It is the view of the AE-PCOS Society Task Force that PCOS should be defined by the presence of hyperandrogenism, ovarian dysfunction, and/or polycystic ovaries, and the exclusion of related disorders.
Journal ArticleDOI
Transdermal testosterone treatment in women with impaired sexual function after oophorectomy
Jan L. Shifren,Glenn D. Braunstein,James A. Simon,Peter R. Casson,John E. Buster,Geoffrey P. Redmond,Regula E. Burki,Elizabeth S. Ginsburg,Raymond C. Rosen,Sandra R. Leiblum,Kim E. Caramelli,Norman A. Mazer +11 more
TL;DR: In women who have undergone oophorectomy and hysterectomy, transdermal testosterone improves sexual function and psychological well-being in women who had impaired sexual function after surgically induced menopause.
Journal ArticleDOI
Hirsutism: Implications, etiology, and management☆
TL;DR: The treatment of hirsutism resulting from functional ovarian hyperandrogenism is not as satisfactory; estrogen-progestin treatment is the most useful adjunct to cosmetic approaches to hirsUTism in this country.
Journal ArticleDOI
Episodic Luteinizing Hormone Secretion in Man PULSE ANALYSIS, CLINICAL INTERPRETATION, PHYSIOLOGIC MECHANISMS
Richard J. Santen,C. W. Bardin +1 more
TL;DR: In this article, the authors demonstrate that luteinizing hormone (LH) release from the pituitary is episodic rather than constant, which raises fundamental questions regarding the physiologic control of pulsatile LH secretion and its possible alteration in patients with gonadal disorders.
References
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Book
Nonparametric statistics for the behavioral sciences
TL;DR: This is the revision of the classic text in the field, adding two new chapters and thoroughly updating all others as discussed by the authors, and the original structure is retained, and the book continues to serve as a combined text/reference.