Journal ArticleDOI
Fatty acyl Δ6 desaturation activity of cultured human endothelial cells modulation by fetal bovine serum
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TLDR
The results indicate that, despite previously published reports to the contrary, human vascular endothelial cells are similar to other normal mammalian cells in having fatty acyl Δ6-desaturase activity.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1983-03-01. It has received 53 citations till now. The article focuses on the topics: Fetal bovine serum & Linolenate.read more
Citations
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Journal ArticleDOI
Membrane lipid composition and cellular function.
Arthur A. Spector,Mark A. Yorek +1 more
TL;DR: Membrane fatty acid composition, phospholipid composition, and cholesterol content can be modified in many different kinds of intact mammalian cells, and many of the functional responses probably are caused directly by the membrane lipid structural changes, which affect either bulk lipid fluidity or specific lipid domains.
Journal ArticleDOI
Eicosapentaenoic acid and prostacyclin production by cultured human endothelial cells.
TL;DR: Findings suggest that regimens designed to reduce platelet aggregation and thrombosis by EPA enrichment may also reduce the capacity of the endothelium to produce PGI2.
Journal ArticleDOI
Role of the blood-brain barrier in the formation of long-chain omega-3 and omega-6 fatty acids from essential fatty acid precursors.
TL;DR: The findings suggest that the blood‐brain barrier can play an important role in the elongation and desaturation of ω‐3 and ω-6 essential fatty acids during their transfer from the circulation into the brain.
Journal ArticleDOI
Arachidonoyl-CoA synthetase. Separation from nonspecific acyl-CoA synthetase and distribution in various cells and tissues.
TL;DR: The levels of arachidonoyl and nonspecific acyl-CoA synthetase in 13 different human cells and tissues are determined, and it is confirmed that arachidonic acid is widely distributed and is present in significantly lower concentrations than nonspecial acyl -CoA Synthetase only in adipose tissue and liver.
References
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Journal ArticleDOI
Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls.
S Moncada,J R Vane +1 more
TL;DR: Prostaglandins are potent vasoactive agents with a wide variety of other actions that depend on the species and organ tested and the prostaglandin used.
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Effect of Saturated and Unsaturated Fatty Acids on the Desaturation in Vitro of Palmitic, Stearic, Oleic, Linoleic, and Linolenic Acids
TL;DR: Quantitative oxidative desaturation of labeled palmitic, stearic, oleic, linoleic, and linolenic acids was studied by gas-liquid radiochromatography after incubation of the acids in a medium containing adenosine triphosphate, reduced nicotinamide adenine dinucleotide, MgCl2, coenzyme A, glutathione, Nicotinamide, NaF, and NaCN in oxygen at pH 7 and 35°.
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Stimulation of arterial endothelial cell prostacyclin synthesis by high density lipoproteins.
TL;DR: The data indicate that HDL stimulates PGI2 synthesis by cultured arterial endothelial cells, possibly by providing the cells with arachidonate.
Journal ArticleDOI
Lipid nutrition and metabolism of cultured mammalian cells
TL;DR: emphasis will be placed on fatty acids, phospholipids and glycerides, and no attempt will be made to treat sterol metabolism comprehen-