FcγRIIIa-158V/F Polymorphism Influences the Binding of IgG by Natural Killer Cell FcγRIIIa, Independently of the FcγRIIIa-48L/R/H Phenotype
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TLDR
Differences in IgG binding among the three Fc gammaRIIIa-48L/R/H isoforms are a consequence of the linked, biallelic Fc Gamma receptor IIIa-158V/F polymorphism at amino-acid position 158.About:
This article is published in Blood.The article was published on 1997-08-01 and is currently open access. It has received 779 citations till now. The article focuses on the topics: CD16 & FCGR3A.read more
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Journal ArticleDOI
Lack of Fucose on Human IgG1 N-Linked Oligosaccharide Improves Binding to Human FcγRIII and Antibody-dependent Cellular Toxicity
Robert L. Shields,Jadine Lai,Rodney G. Keck,Lori Y. O'Connell,Kyu Hong,Y. Gloria Meng,Stefanie Weikert,Leonard G. Presta +7 more
TL;DR: Antibody-dependent cellular cytot toxicity assays using purified peripheral blood monocytes or natural killer cells from several donors showed enhanced cytotoxicity, especially evident at lower antibody concentrations.
Journal ArticleDOI
Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene
Guillaume Cartron,Laurent Dacheux,Gilles Salles,Philippe Solal-Celigny,Pierre Bardos,Philippe Colombat,Hervé Watier +6 more
TL;DR: This study showed an association between the FCGR3A genotype and clinical and molecular responses to rituximab, and will certainly give rise to new pharmacogenetic approaches to the management of patients with non-Hodgkin lymphomas.
Journal ArticleDOI
High Resolution Mapping of the Binding Site on Human IgG1 for FcγRI, FcγRII, FcγRIII, and FcRn and Design of IgG1 Variants with Improved Binding to the FcγR
Robert L. Shields,Angela K. Namenuk,Kyu Hong,Y. Gloria Meng,Julie Rae,Josephine P. Briggs,Dong Xie,Jadine Lai,Andrew Stadlen,Betty Li,Judith A. Fox,Leonard G. Presta +11 more
TL;DR: Select IgG1 variants with improved binding to FcγRIIIA exhibited up to 100% enhancement in antibody-dependent cell cytotoxicity using human effector cells; these variants included changes at residues not found at the binding interface in the IgG/Fcγ RIIIA co-crystal structure.
Patent
Polypeptide variants with altered effector function
TL;DR: In this article, the present invention concerns polypeptides comprising a variant of the Fc region, which have altered effector function as a consequence of one or more amino acid modifications in the region thereof.
Journal ArticleDOI
Two Immunoglobulin G Fragment C Receptor Polymorphisms Independently Predict Response to Rituximab in Patients With Follicular Lymphoma
Wen-Kai Weng,Ronald Levy +1 more
TL;DR: Data support the hypothesis that ADCC plays an important role in the clinical effect of rituximab at the level of the effector cell.
References
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Journal ArticleDOI
Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions.
Jeffrey V. Ravetch,B Perussia +1 more
TL;DR: Two nearly identical, linked genes that encode these transcripts have been cloned for Fc gamma RIII(CD16), one of which (III-1) is allelic for NA- 1 and NA-2, and the allelic sites have been mapped to two single nucleotides in the extracellular domain.
Book ChapterDOI
Molecular basis of Fc receptor function.
Mark D. Hulett,P. Mark Hogarth +1 more
TL;DR: The structural analysis of the functional basis of FcγR and FCɛR signaling is beginning to shed some light on the way these receptors trigger biological responses, and the molecular dissection of the pathways involved in signaling is also underway.
Journal ArticleDOI
Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans.
Jane E. Salmon,S. Sean Millard,S. Sean Millard,Leah A. Schachter,Leah A. Schachter,Frank C. Arnett,Ellen M. Ginzler,Mark F. Gourley,Rosalind Ramsey-Goldman,Margaret G. E. Peterson,Margaret G. E. Peterson,Robert P. Kimberly,Robert P. Kimberly +12 more
TL;DR: The skewing in the distribution of Fc gamma RIIA alleles identifies this gene as a risk factor with pathophysiologic importance for the SLE diathesis in African Americans.
Journal Article
Human natural killer cells analyzed by B73.1, a monoclonal antibody blocking Fc receptor functions. I. Characterization of the lymphocyte subset reactive with B73.1
TL;DR: It is demonstrated that virtually all lymphocytes with K/NK cytotoxic activity are found in the lymphocyte subpopulation bearing the B73.1(+) lymphocyte subset, which corresponds to the lymphocytes subset containing antibody-dependent killer (K) and natural killer (NK) cells.
Journal ArticleDOI
On the interaction of IgG subclasses with the low affinity Fc gamma RIIa (CD32) on human monocytes, neutrophils, and platelets. Analysis of a functional polymorphism to human IgG2.
Paul W. H. I. Parren,P. A. M. Warmerdam,L. C. M. Boeije,J. Arts,Nomdo A.C. Westerdaal,A. Vlug,Peter J.A. Capel,Lucien A. Aarden,J. G. J. Van De Winkel +8 more
TL;DR: The role of Fc gamma RIIa in binding of stable hIgG-subclass dimers, and in induction of T cell mitogenesis using chimeric anti-CD3 mAb is analyzed and it is demonstrated that the functional polymorphism to hIGG2 is expressed on the majority of F c gamma R-bearing peripheral blood cells: monocytes, neutrophils, and platelets.
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Two Immunoglobulin G Fragment C Receptor Polymorphisms Independently Predict Response to Rituximab in Patients With Follicular Lymphoma
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