Feedback between p21 and reactive oxygen production is necessary for cell senescence
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Cites background from "Feedback between p21 and reactive o..."
...Such signaling is also accompanied by the slow (occurring over days) activation of other signaling pathways, such as those governed by the stress-responsive p38MAPK and protein kinase C pathways, and increased reactive oxygen species, which also participate in signaling pathways (53, 57, 76, 77) (Figure 2)....
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1,838 citations
Cites background from "Feedback between p21 and reactive o..."
...A recent systems biology study has suggested that ROS mediates senescence through induction of DNA damage foci, with a contribution of p21CIP1 (Passos et al. 2010)....
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...A recent systems biology study has suggested that ROS mediates senescence through induction of DNA damage foci, with a contribution of p21 (Passos et al. 2010)....
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"Feedback between p21 and reactive o..." refers background or methods in this paper
...Network analysis was performed using the Cytoscape platform (Shannon et al, 2003)....
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...This also enabled us to deal appropriately with molecular species present only at very low copy number (e.g. DNA damage foci) and with fractions of cells developing distinct outcomes (e.g. re-enter proliferation after intervention)....
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"Feedback between p21 and reactive o..." refers methods in this paper
...uk; Kirkwood et al, 2003; Gillespie et al, 2006) using stochastic simulation based on the exact Gillespie algorithm (Gillespie, 1977)....
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...Simulations are run in the Biology of Ageing e-Science Integration and Simulation (BASIS) system (http://www. basis.ncl.ac.uk; Kirkwood et al, 2003; Gillespie et al, 2006) using stochastic simulation based on the exact Gillespie algorithm (Gillespie, 1977)....
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6,696 citations
"Feedback between p21 and reactive o..." refers background in this paper
...There is evidence that senescence-marker-positive cells increase with age in various tissues (Dimri et al, 1995; Krishnamurthy et al, 2004; Herbig et al, 2006; Wang et al, 2009) and in age-related diseases including atherosclerosis (Minamino and Komuro, 2007) and diabetes (Sone and Kagawa, 2005)....
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...…away efficiently from tissues under some conditions (Ventura et al, 2007; Krizhanovsky et al, 2008), cells bearing various senescence markers including DNA damage foci do accumulate in human (Dimri et al, 1995), primate (Herbig et al, 2006) and mouse (Wang et al, 2009) tissues with advancing age....
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...This result might be relevant for therapeutic studies aiming to modulate intracellular ROS levels in both aging and cancer....
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...Feedback between p21 and reactive oxygen production is necessary for cell senescence...
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3,794 citations
"Feedback between p21 and reactive o..." refers background or methods in this paper
...This licence does not permit commercial exploitation or the creation of derivative works without specific permission....
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...Major limitations of interactomes are their limited directionality and their static nature....
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...We first searched an interactome database combining Biogrid (Stark et al, 2006) and Phospho....
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...Bioinformatics and quantitative stochastic modelling A probabilistic functional integrated network of interactions was constructed using gene and protein interaction data from the BioGrid database (Stark et al, 2006), plus protein phosphorylation data from Phospho....
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...As first steps to overcome these limitations, we combined Biogrid data with Phospho....
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