Journal ArticleDOI
Ferric sulfate hydrate-catalyzed O-glycosylation using glycals with or without microwave irradiation
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TLDR
In this paper, a novel glycal-based O-glycosylation reaction, in which the substrates are not only peracetyl glycals but also perbenzyl glucals to afford the corresponding 2,3-unsaturated-O-glucosides via Ferrier rearrangement, was developed.About:
This article is published in Tetrahedron.The article was published on 2008-01-07. It has received 66 citations till now. The article focuses on the topics: Glucal & Ferrier rearrangement.read more
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Iron-catalysed carbon–heteroatom and heteroatom–heteroatom bond forming processes
TL;DR: This tutorial review summarises recent progress in the development of novel and practical iron-catalysed reactions with a particular focus on those which provide access to new carbon-heteroatom and heteroatom-heteroa linkages.
Journal ArticleDOI
Organic synthesis with the most abundant transition metal–iron: from rust to multitasking catalysts
TL;DR: The field of iron catalysis has been explored in the last two-three decades out of its rich chemistry depending on its oxidation states and ligand cooperation as discussed by the authors, and this field has been enriched by the promising development of iron-catalyzed reactions namely, C-H bond activation, including organometallic C−H activation and C−h functionalization via outer-sphere pathway, crossdehydrogenative couplings, insertion reactions, cross-coupling reactions, hydrogenations including hydrogen borrowing reactions, hydrosilylation and hydroboration, addition reactions
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Recent Developments in the Ferrier Rearrangement
TL;DR: A review of recent developments in the use of promoters for the Ferrier rearrangement of O-, N-, C- and S-nucleophiles with glycals can be found in this paper.
Journal ArticleDOI
Iron‐Catalyzed Ligand‐Free Three‐Component Coupling Reactions of Aldehydes, Terminal Alkynes, and Amines
Pinhua Li,Yicheng Zhang,Lei Wang +2 more
TL;DR: A tri-umph in many respects: The iron-catalyzed ligand-free, one-pot three-component coupling reactions of aldehydes, terminal alkynes, and amines in the presence of 4 A molecular sieves yields the corresponding propargylamines in good to excellent yields.
References
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Journal ArticleDOI
Target-oriented and diversity-oriented organic synthesis in drug discovery.
TL;DR: Several synthetic planning principles for diversity-oriented synthesis and their role in the drug discovery process are presented in this review.
Journal ArticleDOI
Glycals in Organic Synthesis: The Evolution of Comprehensive Strategies for the Assembly of Oligosaccharides and Glycoconjugates of Biological Consequence
TL;DR: This review provides a personal account of the explorations of a research group in oligosaccharide and glycoconjugate construction that led to novel compounds which are in the final stages of preclinical assessment.
Journal ArticleDOI
Diversity-oriented synthesis; a challenge for synthetic chemists
TL;DR: This personal account details why DOS has such enormous implications for the discovery of small molecules with desired properties, such as catalysts, synthetic reagents, biological probes and new drugs.
Book
Monosaccharides: Their Chemistry and Their Roles in Natural Products
P. M. Collins,Robin Ferrier +1 more
TL;DR: In this paper, the Chemical Synthesis of Oligosaccharides and Enantiomerically Pure Non-Carbohydrate Compounds by Use of Monosacscharides.
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Unsaturated carbohydrates. Part IX. Synthesis of 2,3-dideoxy-α-D-erythro-hex-2-enopyranosides from tri-O-acetyl-D-glucal
R. J. Ferrier,N. Prasad +1 more
TL;DR: Tri-O-acetyl-D-glucal undergoes complete reaction with alcohols in benzene solution in the presence of boron trifluoride to give 4,6-di-OðOðAðEðDÞÞ −2,3-dideoxy-α-DÒÞ−EðE Þ−hex-hex-2-enopyranosyl as discussed by the authors, which can be used to prepare the known crystalline ethyl αglucoside easily and in greatly improved
Related Papers (5)
Stereoselective palladium-catalyzed O-glycosylation using glycals
Hahn Kim,Hongbin Men,Chulbom Lee +2 more