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Fibre-reinforced calcium phosphate cements: a review.
Cristina Canal,Maria-Pau Ginebra +1 more
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TLDR
The present work aims at providing an overview of the different approaches taken and identifying the most significant achievements in the field of fibre-reinforced calcium phosphate cements for clinical applications, with special focus on their mechanical properties.Abstract:
Calcium phosphate cements (CPC) consist of one or more calcium orthophosphate powders, which upon mixing with water or an aqueous solution, form a paste that is able to set and harden after being implanted within the body. Different issues remain still to be improved in CPC, such as their mechanical properties to more closely mimic those of natural bone, or their macroporosity to favour osteointegration of the artificial grafts. To this end, blends of CPC with polymer and ceramic fibres in different forms have been investigated. The present work aims at providing an overview of the different approaches taken and identifying the most significant achievements in the field of fibre-reinforced calcium phosphate cements for clinical applications, with special focus on their mechanical properties.read more
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Sol-gel based materials for biomedical applications
Gareth J Owens,Rajendra K. Singh,Farzad Foroutan,Mustafa Alqaysi,Cheol-Min Han,Chinmaya Mahapatra,Hae-Won Kim,Jonathan C. Knowles,Jonathan C. Knowles +8 more
TL;DR: A more detailed description of the biomedical areas where sol-gel materials have been explored and found to hold significant potential is given in this paper, where a generalized description of various solgel methods available and how these chemistries control the bulk properties of the end products is presented.
Journal ArticleDOI
Calcium phosphate cements for bone substitution: chemistry, handling and mechanical properties.
TL;DR: An overview on the chemistry, kinetics of setting and handling properties (setting time, cohesion and injectability) of CPCs for bone substitution, with a focus on their mechanical properties shows that, although the mechanical strength of CPC's is generally low, it is not a critical issue for their application for bone repair.
Journal ArticleDOI
Calcium phosphate cements as drug delivery materials.
TL;DR: An overview of the different approaches taken in the application of calcium phosphate cements for drug delivery in the skeletal system is provided, and the most significant achievements are identified.
Journal ArticleDOI
Calcium phosphate cements for bone engineering and their biological properties.
Hockin H.K. Xu,Ping Wang,Ping Wang,Lin Wang,Lin Wang,Chongyun Bao,Qianming Chen,Michael D. Weir,Laurence C. Chow,Liang Zhao,Liang Zhao,Xuedong Zhou,Mark A. Reynolds +12 more
TL;DR: This review article focuses on the major recent developments in CPCs, including 3D printing, injectability, stem cell delivery, growth factor and drug delivery, and pre-vascularization of CPC scaffolds via co-culture and tri-culture techniques to enhance angiogenesis and osteogenesis.
Journal ArticleDOI
Reaction kinetics of dual setting α-tricalcium phosphate cements
Katrin Hurle,Theresa Christel,Uwe Gbureck,Claus Moseke,Juergen Neubauer,Friedlinde Goetz-Neunhoeffer +5 more
TL;DR: While the extent of CDHA formation was decreased, the mechanical properties were noticeably improved by addition of HEMA, suggesting α-TCP/HEMA composites might be suitable for application in some load-bearing defects and have adequate properties for mechanical treatment after implantation, like insertion of screws.
References
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