Journal ArticleDOI
Fibrinogen as a therapeutic target for bleeding: a review of critical levels and replacement therapy.
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TLDR
Results show that fibrinogen concentrate is associated with a reduction or even total avoidance of allogeneic blood product transfusion, and represents an important option for the treatment of coagulopathic bleeding; further studies are needed to determine precise dosing strategies and thresholds for fibr inogen supplementation.About:
This article is published in Transfusion.The article was published on 2014-05-01. It has received 253 citations till now. The article focuses on the topics: Fibrinogen & Hemostasis.read more
Citations
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Journal ArticleDOI
Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage: A Statement for Healthcare Professionals from the Neurocritical Care Society and Society of Critical Care Medicine.
Jennifer A. Frontera,John J. Lewin,Alejandro A. Rabinstein,Imo P. Aisiku,Anne W. Alexandrov,Anne W. Alexandrov,Aaron M. Cook,Gregory J. del Zoppo,Monisha A. Kumar,Ellinor I.B. Peerschke,Michael F. Stiefel,Jeanne Teitelbaum,Katja E. Wartenberg,Cindy L. Zerfoss +13 more
TL;DR: This guideline provides timely, evidence-based reversal strategies to assist practitioners in the care of patients with antithrombotic-associated intracranial hemorrhage.
Journal ArticleDOI
Management of the critically ill patient with cirrhosis: A multidisciplinary perspective
Mitra K. Nadim,François Durand,John A. Kellum,Josh Levitsky,Jacqueline G. O'Leary,Constantine J. Karvellas,Jasmohan S. Bajaj,Andrew Davenport,Rajiv Jalan,Paolo Angeli,Stephen H. Caldwell,Javier Fernández,Claire Francoz,Guadalupe Garcia-Tsao,Pere Ginès,Michael G. Ison,David J. Kramer,Ravindra L. Mehta,Richard Moreau,David C. Mulligan,Jody C. Olson,Elizabeth A. Pomfret,Marco Senzolo,Randolph H. Steadman,Ram M. Subramanian,Jean Louis Vincent,Yuri Genyk +26 more
TL;DR: The management of the critically ill patient with cirrhosis: A multidisciplinary perspective is presented from a multi-disciplinary perspective.
Journal ArticleDOI
Pre-emptive treatment with fibrinogen concentrate for postpartum haemorrhage: randomized controlled trial
A.J. Wikkelsø,H.M. Edwards,A. Afshari,J. Stensballe,J. Langhoff-Roos,C. Albrechtsen,K. Ekelund,G. Hanke,E.L. Secher,H.F. Sharif,L.M. Pedersen,A. Troelstrup,J. Lauenborg,A.U. Mitchell,L. Fuhrmann,J. Svare,M.G. Madsen,B. Bødker,A.M. Møller,Anne Wikkelsø,Hellen Mc Kinnon Edwards,Arash Afshari,Jakob Stensballe,Jens Langhoff-Roos,Ann Merete Møller,Charlotte Albrechtsen,Kim Ekelund,Gabriele Hanke,Heidi F Sharif,Erik L. Secher,Marina K. Christensen,Benedicte Utke Ramsing,Peter Jensen-Gadegaard,Anna Engskov,C. B. Wulff,Marianne Berntsen,Kristian J. Andersen,Volker Classen,Pernille Opstrup,Lars Hyldborg Lundstrøm,Marianne S. Flindt,Jens Lunde,Lars Møller Pedersen,Ane Troelstrup,Jeannet Lauenborg,Birgit Lassen,Mette Andersson,Marie Winther-Olsen,Sine Hougaard,Christine Andersen,Maria Petersen,Anja U. Mitchell,Lone Fuhrmann,Jens Svare,Christian Viggo Nielsen,Michelé Lefort Sønderskov,Rasmus Winkel,Mathias Johansen,Marie Søgaard,Mette G. Madsen,Birgit Bødker,Casper Okkels,Rasmus Berthelsen,Karen Elisabeth Linnet,Line Stendall,Iben Darfeld,M. H. Madsen,Louise Pedersen +67 more
TL;DR: No evidence is found for the use of 2 g fibrinogen concentrate as pre-emptive treatment for severe PPH in patients with normofibr inogenaemia.
Journal ArticleDOI
Coagulation parameters and major bleeding in critically ill patients with cirrhosis.
Andreas Drolz,Thomas Horvatits,Kevin Roedl,Karoline Rutter,Katharina Staufer,Nikolaus Kneidinger,Ulrike Holzinger,Christian Zauner,Peter Schellongowski,Gottfried Heinz,Thomas Perkmann,Stefan Kluge,Michael Trauner,Valentin Fuhrmann +13 more
TL;DR: Abnormal coagulation parameters and high DIC scores correspond to increased bleeding risk in patients with liver cirrhosis in the intensive care unit, and fibrinogen and platelet count were identified as the best routine coagulated parameters for prediction of new onset of major bleeding; however, further studies are required to evaluate the potential therapeutic implications of these findings.
Journal ArticleDOI
How I use fibrinogen replacement therapy in acquired bleeding
TL;DR: Point-of-care testing will have an important role in guiding fibrinogen replacement for hemostatic therapy in clinical settings such as cardiovascular surgery, postpartum hemorrhage, and trauma.
References
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Journal ArticleDOI
Mortality by cause for eight regions of the world: Global Burden of Disease Study
TL;DR: The Global Burden of Disease Study (GBD) used various data sources and made corrections for miscoding of important diseases (eg, ischaemic heart disease) to estimate worldwide and regional cause-of-death patterns in 1990, and the estimates by cause provide a foundation for a more informed debate on public-health priorities.
Journal ArticleDOI
The global burden of injuries.
TL;DR: Public health officials must gain a better understanding of the magnitude and characteristics of the problem, contribute to the development and evaluation of injury prevention programs, and develop the best possible prehospital and hospital care and rehabilitation for injured persons.
Journal ArticleDOI
Management of severe perioperative bleeding Guidelines from the European Society of Anaesthesiology
Sibylle A. Kozek-Langenecker,Arash Afshari,Pierre Albaladejo,Cesar Aldecoa Alvarez Santullano,Edoardo De Robertis,Daniela Filipescu,Dietmar Fries,Thorsten Haas,Georgina Imberger,Matthias Jacob,Marcus D. Lancé,Juan V. Llau,Susan Mallett,Jens Meier,Niels Rahe-Meyer,Charles Marc Samama,Andrew Smith,Cristina Solomon,Philippe Van der Linden,Anne Wikkelsø,Patrick Wouters,Piet Wyffels +21 more
TL;DR: These guidelines are intended to provide an overview of current knowledge on the subject with an assessment of the quality of the evidence in order to allow anaesthetists throughout Europe to integrate this knowledge into daily patient care wherever possible.
Journal ArticleDOI
Practice guidelines for perioperative blood transfusion and adjuvant therapies: An updated report by the American Society of Anesthesiologists Task Force on perioperative blood transfusion and adjuvant therapies
Gregory A. Nuttall,Brian C. Brost,Richard T. Connis,James S. Gessner,Chantal R. Harrison,Ronald D. Miller,David G. Nickinovich,Nancy A. Nussmeier,Andrew D. Rosenberg,Richard Spence +9 more
Journal ArticleDOI
Management of bleeding and coagulopathy following major trauma: an updated European guideline
Donat R. Spahn,Bertil Bouillon,Vladimir Cerny,Timothy J Coats,Jacques Duranteau,Enrique Fernández-Mondéjar,Daniela Filipescu,Beverley J. Hunt,Radko Komadina,Giuseppe Nardi,Edmund Neugebauer,Yves Ozier,Louis Riddez,Arthur Schultz,Jean Louis Vincent,Rolf Rossaint +15 more
TL;DR: Key changes encompassed in this version of the guideline include new recommendations on the appropriate use of vasopressors and inotropic agents, and reflect an awareness of the growing number of patients in the population at large treated with antiplatelet agents and/or oral anticoagulants.
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