Fibroblast growth factor signalling: from development to cancer
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Cites background from "Fibroblast growth factor signalling..."
...FGFR signaling plays a key role in many functions including cell proliferation, survival and migration, and can promote cancer development by affecting a range of major downstream processes.(16) An emerging body of evidence has identified roles for FGFR signaling in oncogenic processes, including proliferation, survival, migration and angiogenesis....
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...An emerging body of evidence has identified roles for FGFR signaling in oncogenic processes, including proliferation, survival, migration and angiogenesis.(16)...
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1,014 citations
References
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"Fibroblast growth factor signalling..." refers background in this paper
...and metastasize, it must establish its own blood supply to provide oxygen and nutrient...
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4,628 citations
"Fibroblast growth factor signalling..." refers background in this paper
..., and importantly the kinetics of signalling, with sustained strong signalling inducing differentiation, senescence and apoptosis, and less pronounced signalling inducing proliferation and surviva...
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3,234 citations
"Fibroblast growth factor signalling..." refers background in this paper
...Initial studies showed a key role for FGF signalling in epithelial repair but some FGF members, in particular FGF2, are known to be important for new blood vessel growth at the wound site (reviewed in Ref...
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"Fibroblast growth factor signalling..." refers background in this paper
...The importance of FGF signalling in tumour pathogenesis was highlighted by a screen of more than 1,000 somatic mutations found in the coding exons of 518 protein kinase genes from 210 different human cancer...
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