Fibroblast growth factors, their receptors and signaling.
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TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
Citations
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Allergen-Induced Coexpression of bFGF and TGF-β1 by Macrophages in a Mouse Model of Airway Remodeling: bFGF Induces Macrophage TGF-β1 Expression in vitro
TL;DR: This study demonstrates that allergen challenge stimulates peribronchial macrophages to coexpress bFGF and TGF-β1 and that bF GF may potentiate macrophage release of TGF -β1 through autocrine and/or paracrine pathways.
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Pivotal Role of Translokin/CEP57 in the Unconventional Secretion Versus Nuclear Translocation of FGF2
Sylvain Meunier,Marina GarcÃa-Jove Navarro,Marina GarcÃa-Jove Navarro,Carine Bossard,Henrik Laurell,Henrik Laurell,Christian Touriol,Christian Touriol,Eric Lacazette,Eric Lacazette,Hervé Prats,Hervé Prats +11 more
TL;DR: The identification of four Translokin partners: sorting nexin 6, Ran‐binding protein M and the kinesins KIF3A and Kif3B are reported, involved in two exclusive complexes allowing the bidirectional trafficking of FGF2.
Journal ArticleDOI
Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state
TL;DR: The regulatory effects of FGF15/19 and FGF21 on metabolism in the fast and fed states are reviewed to provide some insight into the metabolic regulation of FGEs in different physiological condition.
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The influence of FGF2 high molecular weight (HMW) isoforms in the development of cardiac ischemia-reperfusion injury
Siyun Liao,Janet R. Bodmer,Mohamad Azhar,Mohamad Azhar,Gilbert Newman,J. Douglas Coffin,Thomas Doetschman,Thomas Doetschman,Jo El J. Schultz +8 more
TL;DR: Overall, the data indicate that HMW isoforms have a detrimental role in the development of post-ischemic myocardial dysfunction.
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Long-acting hypoglycemic effects of PEGylated FGF21 and insulin glargine in mice with type 1 diabetes.
Pengfei Xu,Xianlong Ye,Yingjie Zhang,Qingyan Yuan,Mingyao Liu,Qiang Wu,Guiping Ren,Deshan Li +7 more
TL;DR: PEG-FGF21 achieves glucose clearance by accelerating glycolysis by up-regulating expression of GK and GLUT1 and inhibiting gluconeogenesis via down-regulation of G6Pase and PEPCK expression through qRT-PCR.
References
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Journal ArticleDOI
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
Journal ArticleDOI
Protein modules and signalling networks
TL;DR: This work highlights conserved protein domains that act as key regulatory participants in many of these different signalling pathways in multicellular organisms.
Journal ArticleDOI
Thalidomide is an inhibitor of angiogenesis.
TL;DR: Electron microscopic examination of the corneal neovascularization of thalidomide-treated rabbits revealed specific ultrastructural changes similar to those seen in the deformed limb bud vasculature of Thalidomid-treated embryos.
Journal ArticleDOI
Receptor specificity of the fibroblast growth factor family.
David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.