Fibroblast growth factors, their receptors and signaling.
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TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
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Intravitreal injection of the heparin analog 5-amino-2-naphthalenesulfonate reduces retinal neovascularization in mice.
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Expression and possible function of fibroblast growth factor 9 (FGF9) and its cognate receptors FGFR2 and FGFR3 in postnatal and adult retina
Ayca Cinaroglu,Yesim Ozmen,Anil Ozdemir,Ferruh Ozcan,Ferruh Ozcan,Ceren Ergorul,Ceren Ergorul,Pelin Cayirlioglu,Pelin Cayirlioglu,David Hicks,Kuyas Bugra +10 more
TL;DR: A role for FGF9 in retinal differentiation and maturation is suggested, possibly representing a neuronally derived factor acting upon glial (and other) cells.
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Cartilage engineering from mesenchymal stem cells.
TL;DR: Growth factors most commonly used for in vitro cultivation of cartilage tissue belong to the fibroblast growth factor (FGF) family, the transforming growth factor-beta (TGF-β) super-family, and the insulin-like growth factors (IGF) family.
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Sulfated derivatives of Escherichia coli K5 polysaccharides as modulators of fibroblast growth factor signaling.
TL;DR: The data suggest that highly O-sulfated species of K5PS may be efficient inhibitors of FGF signaling, and the potential of sulfated derivatives of a bacterial polysaccharide from Escherichia coli K5 (K5PS) in the modulation of F GF-heparin/HS interactions and F GF signaling.
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Fibroblast growth factor 8 is expressed at higher levels in lactating human breast and in breast cancer
TL;DR: An immunohistochemistry study of fibroblast growth factor 8 expression in a series of human breast tissues and other normal tissues confirms increased expression in malignant breast tissue but also show significant fibro Blast growth factor8 expression in non-malignant breast epithelial cells.
References
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David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.