Fibroblast growth factors, their receptors and signaling.
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...…that are regulated by, and mediate transcriptional effects of FGF8 are ECM remodeling enzymes (Brent and Tabin, 2004; Firnberg and Neubuser, 2002; Moon et al., 2006; Park et al., 2006; Raible and Brand, 2001; Roehl and Nusslein-Volhard, 2001; Crawford et al., 2001; Crawford andMatrisian, 1996)....
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18 citations
Cites background from "Fibroblast growth factors, their re..."
...…and play important roles in the regulation of proliferation, differentiation, and angiogenesis, as well as in other processes involved in growth and development (Gospodarowicz et al., 1986; Burgess and Maciag, 1989; Hughes, 1997; Boilly et al., 2000; Powers et al., 2000; Ornitz and Itoh, 2001)....
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18 citations
Cites background from "Fibroblast growth factors, their re..."
...Of these activities, members of the fibroblast growth factor (FGF) family, including FGF-7 and FGF10, depend on GAGs to participate in important wound repair events including inflammation, repair and regeneration [9] [10]....
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18 citations
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...FGF-2, the prototypic member of a family of related genes encoding heparin-binding proteins with growth-, antiapoptotic- and survival-promoting activity [3], has also been shown to contribute to malignant progression by increasing genetic instability [4] and resistance to anticancer drugs [5]....
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18 citations
Cites background from "Fibroblast growth factors, their re..."
...For example, splicing of FGFR2 results in two variants, e.g. FGFR2IIIb, which is highly specific for binding FGF7 and FGF10 (Lu et al. 1999, Ornitz 2000, Ornitz & Itoh 2001), and FGFR2IIIc, which binds other ligands such as FGF1 and FGF8 (Ornitz 2000, Powers et al. 2000)....
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References
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"Fibroblast growth factors, their re..." refers background in this paper
...One way these recruited target proteins may be localized to the activated receptor is through the interaction between their Src-homology 2 (SH2) domains and specific phosphotyrosine residues on the activated receptor (Pawson 1995)....
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...Phosphorylated tyrosine residues, in turn, recruit other signaling molecules to the activated receptors and propagate the signal through many possible transduction pathways (Pawson 1995)....
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2,364 citations
2,066 citations
"Fibroblast growth factors, their re..." refers background in this paper
...†From Ornitz et al. (1996), except where stated; ‡From Koga et al. (1995); §From Miralles et al. (1999); ¶From Xu et al. (1999). topologically identical to interleukin-1β (IL-1β) (Zhu et al. 1991), with which some members also share the feature of secretion by an endoplasmic reticulum…...
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...Mutation of all four cysteines to serines results in a protein with the same secondary structure and equally mitogenic for 3T3 cells as the wild-type FGF-2 (Foxet al. 1988), suggesting that the formation of disulfide bridges is not important for the secondary structure and mitogenic activity of…...
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...Ornitz et al. (1996) determined the specificity of different FGFs for different receptor isoforms by overexpressing these isoforms in Baf3 cells, which do not normally express FGFRs, and assaying for [3H]thymidine incorporation in these cells following treatment with different FGFs (see Table 2)....
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...1, IIIb 100 60 34 16 4 5 6 4 4 1, IIIc 100 104 0 102 59 55 0 1 21 2, IIIb 100 9 45 15 5 5 81 4 7 2, IIIc 100 64 4 94 25 61 2.5 16 89 3, IIIb 100 1 2 1 1 1 1 1 42 3, IIIc 100 107 1 69 12 9 1 41 96 4 100 113 6 108 7 79 2 76 75 Modified from Ornitz et al. (1996)....
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1,994 citations
"Fibroblast growth factors, their re..." refers background in this paper
...Defining features of the FGF family are a strong affinity for heparin and HLGAGs (Burgess & Maciag 1989), as well as a central core of 140 amino acids that is highly homologous between different family members....
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