Fibroblast growth factors, their receptors and signaling.
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...…intracellular region affecting kinase activity or the availability of docking sites for downstream effectors (Ueno et al., 1992; Yan et al., 1993; Wang and Thomas, 1994; Kishi et al., 1994; van Heumen et al., 1999; Powers et al., 2000; Ezzat et al., 2001; Terada et al., 2001; Burgar et al., 2002)....
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15 citations
15 citations
Cites background from "Fibroblast growth factors, their re..."
...Similarly, the other FGF receptors and receptor isoforms, in particular FGFR2, which has been shown to be expressed in human thyroid cells (20), and FGF-binding proteins (33) are of unknown importance....
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...There are four high-affinity membrane FGF receptors identified in humans, FGFR1–FGFR4, which have a common structure of extracellular immunoglobulinlike loops, a transmembrane domain, and an intracellular tyrosine kinase domain (33)....
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...FIBROBLAST GROWTH FACTORS (FGFs) are a large family of heparin-binding growth factors, now comprising 23 members, which have been detected in almost all tissues and shown to be mitogenic to many cell types (16, 33)....
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15 citations
References
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"Fibroblast growth factors, their re..." refers background in this paper
...One way these recruited target proteins may be localized to the activated receptor is through the interaction between their Src-homology 2 (SH2) domains and specific phosphotyrosine residues on the activated receptor (Pawson 1995)....
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...Phosphorylated tyrosine residues, in turn, recruit other signaling molecules to the activated receptors and propagate the signal through many possible transduction pathways (Pawson 1995)....
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2,364 citations
2,066 citations
"Fibroblast growth factors, their re..." refers background in this paper
...†From Ornitz et al. (1996), except where stated; ‡From Koga et al. (1995); §From Miralles et al. (1999); ¶From Xu et al. (1999). topologically identical to interleukin-1β (IL-1β) (Zhu et al. 1991), with which some members also share the feature of secretion by an endoplasmic reticulum…...
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...Mutation of all four cysteines to serines results in a protein with the same secondary structure and equally mitogenic for 3T3 cells as the wild-type FGF-2 (Foxet al. 1988), suggesting that the formation of disulfide bridges is not important for the secondary structure and mitogenic activity of…...
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...Ornitz et al. (1996) determined the specificity of different FGFs for different receptor isoforms by overexpressing these isoforms in Baf3 cells, which do not normally express FGFRs, and assaying for [3H]thymidine incorporation in these cells following treatment with different FGFs (see Table 2)....
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...1, IIIb 100 60 34 16 4 5 6 4 4 1, IIIc 100 104 0 102 59 55 0 1 21 2, IIIb 100 9 45 15 5 5 81 4 7 2, IIIc 100 64 4 94 25 61 2.5 16 89 3, IIIb 100 1 2 1 1 1 1 1 42 3, IIIc 100 107 1 69 12 9 1 41 96 4 100 113 6 108 7 79 2 76 75 Modified from Ornitz et al. (1996)....
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1,994 citations
"Fibroblast growth factors, their re..." refers background in this paper
...Defining features of the FGF family are a strong affinity for heparin and HLGAGs (Burgess & Maciag 1989), as well as a central core of 140 amino acids that is highly homologous between different family members....
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