Fibroblast growth factors, their receptors and signaling.
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TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
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Fast growth associated with aberrant vasculature and hypoxia in fibroblast growth factor 8b (FGF8b) over-expressing PC-3 prostate tumour xenografts.
Johanna Tuomela,Tove J Grönroos,Maija P. Valta,Jouko Sandholm,Aleksi Schrey,Jani Seppänen,Päivi Marjamäki,Sarita Forsback,Ilpo Kinnunen,Olof Solin,Heikki Minn,Pirkko Härkönen,Pirkko Härkönen +12 more
TL;DR: FGF8b is able to induce fast growth in strongly hypoxic tumour microenvironment whereas VEGF-stimulated growth advantage is associated with improved perfusion and oxygenation of prostate tumour xenografts.
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Expression and localization of fibroblast growth factor (FGF) family in corpus luteum during different stages of estrous cycle and synergistic role of FGF2 and vascular endothelial growth factor (VEGF) on steroidogenesis, angiogenesis and survivability of cultured buffalo luteal cells
S.R. Mishra,Mehtab S. Parmar,V.S. Chouhan,G. Rajesh,Vibha Yadav,M.K. Bharti,Jaya Bharati,Tanmay Mondal,R. Reshma,Avishek Paul,S.S. Dangi,Bikas C. Das,Luciano A. González,G. T. Sharma,Gurmej Singh,Mihir Sarkar +15 more
TL;DR: Real-time PCR, western blot, and immunohistochemistry were used to investigate mRNA and protein expressions, and the localization of examined factors whereas P4 secretion was assessed by RIA.
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Critical signal transduction pathways in CLL
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TL;DR: The impact of aberrant activities of various RTKs/non-RTKs on CLL B cell survival and the potential of using these signaling components as future therapeutic targets in CLL therapy is detailed.
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Role of fibroblast growth factor signaling in vascular formation and maintenance: orchestrating signaling networks as an integrated system
TL;DR: Current knowledge is summarized in order to understand the mechanism of this coordination and evaluate the pivotal role of FGF signaling in integrating a diverse range of signaling events in vascular growth and maintenance.
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Plasma VEGF levels in breast cancer patients with and without metastases.
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References
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Journal ArticleDOI
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David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.