Fibroblast growth factors, their receptors and signaling.
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TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
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FGFR a promising druggable target in cancer: Molecular biology and new drugs
Rut Porta,Roberto Borea,Andreia Coelho,Shahanavaj Khan,António Araújo,Pablo Reclusa,Tindara Franchina,Nele Van Der Steen,Peter van Dam,Jose Ferri,Rafael Sirera,Aung Naing,David S. Hong,Christian Rolfo +13 more
TL;DR: This review summarizes the current status of treatments targeting FGFR, focusing on the trials that are evaluating the FGFR profile as inclusion criteria: Multi-Target, Pan-FGFR Inhibitors and anti-FGF (Fibroblast Growth Factor)/FGFR Monoclonal Antibodies.
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Co-receptor requirements for fibroblast growth factor-19 signaling.
Xinle Wu,Hongfei Ge,Jamila Gupte,Jennifer Weiszmann,Grant Shimamoto,Jennitte Stevens,Nessa Hawkins,Bryan Lemon,Wenyan Shen,Jing Xu,Murielle M. Véniant,Yue-Sheng Li,Richard A. Lindberg,Jin-Long Chen,Hui Tian,Yang Li +15 more
TL;DR: The results suggest that a functional FGF19 receptor may consist of FGF receptor (FGFR) and heparan sulfate complexed with either αKlotho or βKlothso, which are related to each other and highly expressed in liver and fat.
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Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3D mammary epithelial cell model.
TL;DR: In this conditional model, an in vitro three-dimensional HC11 mouse mammary epithelial cell culture model expressing a drug-inducible FGFR1 (iFGFR1) led to reinitiation of cell proliferation, increased survival of luminal cells, and loss of cell polarity, resulting in the disruption of acinar structures characterized by the absence of an empty lumen.
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A functional heparan sulfate mimetic implicates both heparanase and heparan sulfate in tumor angiogenesis and invasion in a mouse model of multistage cancer.
TL;DR: It is reported that heparanase mRNA and protein expression are increased in the neoplastic stages progressively unfolding in a mouse model of multistage pancreatic islet carcinogenesis, and it is shown that the reduction in tumor angiogenesis is correlated with a reduced association of VEGF-A with its receptor V EGF-R2 on the tumor endothelium.
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The Fibroblast Growth Factor Receptor-4 Arg388 Allele Is Associated with Prostate Cancer Initiation and Progression
TL;DR: The FGFR-4 Arg388 allele is associated with both an increased incidence and clinical aggressiveness of prostate cancer and results in changes in cellular motility and invasiveness in immortalized prostate epithelial cells consistent with the promotion of metastasis.
References
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