Fibroblast growth factors, their receptors and signaling.
Citations
98 citations
98 citations
Cites background from "Fibroblast growth factors, their re..."
...Fgfrs have three external immunoglobulin-like (Ig-like) domains, a transmembrane (TM) domain, and an intracellular kinase domain (31) (Fig....
[...]
...Alternate splicing of C-terminal portions of the third Ig-like domains of Fgfrs1–3 results in IIIb or IIIc isoforms with different ligand specificities (Fgfr4 only has a IIIc isoform); in the context of embryonic development, Fgfr IIIb and IIIc isoforms have generally been felt to be expressed in and active in epithelium and mesenchyme, respectively (31) (Fig....
[...]
...Molecules, such as fibroblast growth factor receptor substrate 2 (Frs2 ) and phospholipase C (PLC ), transmit Fgfr signals via binding sites that are conserved across different receptor family members (31)....
[...]
...Fibroblast growth factor receptors (Fgfrs) are receptor tyrosine kinases (RTKs) with four signaling family members that have 22 known Fgf ligands in mammals (31)....
[...]
98 citations
Cites background from "Fibroblast growth factors, their re..."
...…functions during embryo development and adult tissue homeostasis, including the regulation of cell proliferation, differentiation, wound healing, angiogenesis and malignant transformation as well as migration and neurite outgrowth (for reviews see Szebenyi and Fallon, 1999; Powers et al., 2000)....
[...]
98 citations
Cites background from "Fibroblast growth factors, their re..."
...Furthermore, alternative mRNA splicing leads to isoforms of FGFR that have unique ligand-binding properties (Powers et al., 2000)....
[...]
...The central role of FGF signaling is underlined not only by the results of our in vitro experiments but also by the large body of literature underscoring the multiple and pleiotropic effect of this conserved signaling pathway (Powers et al., 2000; Ornitz and Marie, 2002; Thiery 2002)....
[...]
98 citations
References
2,448 citations
2,433 citations
"Fibroblast growth factors, their re..." refers background in this paper
...One way these recruited target proteins may be localized to the activated receptor is through the interaction between their Src-homology 2 (SH2) domains and specific phosphotyrosine residues on the activated receptor (Pawson 1995)....
[...]
...Phosphorylated tyrosine residues, in turn, recruit other signaling molecules to the activated receptors and propagate the signal through many possible transduction pathways (Pawson 1995)....
[...]
2,364 citations
2,066 citations
"Fibroblast growth factors, their re..." refers background in this paper
...†From Ornitz et al. (1996), except where stated; ‡From Koga et al. (1995); §From Miralles et al. (1999); ¶From Xu et al. (1999). topologically identical to interleukin-1β (IL-1β) (Zhu et al. 1991), with which some members also share the feature of secretion by an endoplasmic reticulum…...
[...]
...Mutation of all four cysteines to serines results in a protein with the same secondary structure and equally mitogenic for 3T3 cells as the wild-type FGF-2 (Foxet al. 1988), suggesting that the formation of disulfide bridges is not important for the secondary structure and mitogenic activity of…...
[...]
...Ornitz et al. (1996) determined the specificity of different FGFs for different receptor isoforms by overexpressing these isoforms in Baf3 cells, which do not normally express FGFRs, and assaying for [3H]thymidine incorporation in these cells following treatment with different FGFs (see Table 2)....
[...]
...1, IIIb 100 60 34 16 4 5 6 4 4 1, IIIc 100 104 0 102 59 55 0 1 21 2, IIIb 100 9 45 15 5 5 81 4 7 2, IIIc 100 64 4 94 25 61 2.5 16 89 3, IIIb 100 1 2 1 1 1 1 1 42 3, IIIc 100 107 1 69 12 9 1 41 96 4 100 113 6 108 7 79 2 76 75 Modified from Ornitz et al. (1996)....
[...]
1,994 citations
"Fibroblast growth factors, their re..." refers background in this paper
...Defining features of the FGF family are a strong affinity for heparin and HLGAGs (Burgess & Maciag 1989), as well as a central core of 140 amino acids that is highly homologous between different family members....
[...]