Fibroblast growth factors, their receptors and signaling.
Citations
65 citations
Cites background from "Fibroblast growth factors, their re..."
...This induction/ maintenance is guided mainly through the PI3K cascade pathway (a survival/apoptosis pathway; Chen et al., 2000; Ong et al., 2001; Powers et al., 2000), involved in the control of ERK activation (Liu and Joyner, 2001a,b; Nakamura, 2001) through Mkp3, which together with the PI3K…...
[...]
...While Fgf8, through PIK3, performs an essential role in cell survival (Chen et al., 2000; Ong et al., 2001; Powers et al., 2000), as shown in the Fgf8 conditional knockout in which the IsO deletion is due to massive cell death during early neurogenesis (Chi et al....
[...]
...While Fgf8, through PIK3, performs an essential role in cell survival (Chen et al., 2000; Ong et al., 2001; Powers et al., 2000), as shown in the Fgf8 conditional knockout in which the IsO deletion is due to massive cell death during early neurogenesis (Chi et al., 2003)....
[...]
...This induction/ maintenance is guided mainly through the PI3K cascade pathway (a survival/apoptosis pathway; Chen et al., 2000; Ong et al., 2001; Powers et al., 2000), involved in the control of ERK activation (Liu and Joyner, 2001a,b; Nakamura, 2001) through Mkp3, which together with the PI3K pathway are important for mesencephalon/rhombencephalon development....
[...]
...While the activation of the MAPK cascade promotes neural proliferation, differentiation, and apoptosis, activation of the PI3K pathway promotes cell survival (Chen et al., 2000; Ong et al., 2001; Powers et al., 2000)....
[...]
65 citations
Cites background from "Fibroblast growth factors, their re..."
...Functional diversity of FGFRs is regulated by the wide variety of FGF ligands, difference in ligand binding affinity and specificity, as well as the alternative splicing of FGFRmRNAs (Powers et al., 2000)....
[...]
65 citations
64 citations
Cites background from "Fibroblast growth factors, their re..."
...FGFR, like other single transmembrane growth factor receptors, transduces signals across the cell membrane after binding extracellular ligands (Powers et al., 2000)....
[...]
64 citations
Cites background from "Fibroblast growth factors, their re..."
...Several small-molecule kinase inhibitors targeting FGFRs have been developed over the past decade (for review see [155,156])....
[...]
...It is therefore not surprising that most of the FGFR-targeting kinase inhibitors that have reached clinical trial stages II and III are being tested as anti-angiogenic therapeutics [155,156]....
[...]
References
2,448 citations
2,433 citations
"Fibroblast growth factors, their re..." refers background in this paper
...One way these recruited target proteins may be localized to the activated receptor is through the interaction between their Src-homology 2 (SH2) domains and specific phosphotyrosine residues on the activated receptor (Pawson 1995)....
[...]
...Phosphorylated tyrosine residues, in turn, recruit other signaling molecules to the activated receptors and propagate the signal through many possible transduction pathways (Pawson 1995)....
[...]
2,364 citations
2,066 citations
"Fibroblast growth factors, their re..." refers background in this paper
...†From Ornitz et al. (1996), except where stated; ‡From Koga et al. (1995); §From Miralles et al. (1999); ¶From Xu et al. (1999). topologically identical to interleukin-1β (IL-1β) (Zhu et al. 1991), with which some members also share the feature of secretion by an endoplasmic reticulum…...
[...]
...Mutation of all four cysteines to serines results in a protein with the same secondary structure and equally mitogenic for 3T3 cells as the wild-type FGF-2 (Foxet al. 1988), suggesting that the formation of disulfide bridges is not important for the secondary structure and mitogenic activity of…...
[...]
...Ornitz et al. (1996) determined the specificity of different FGFs for different receptor isoforms by overexpressing these isoforms in Baf3 cells, which do not normally express FGFRs, and assaying for [3H]thymidine incorporation in these cells following treatment with different FGFs (see Table 2)....
[...]
...1, IIIb 100 60 34 16 4 5 6 4 4 1, IIIc 100 104 0 102 59 55 0 1 21 2, IIIb 100 9 45 15 5 5 81 4 7 2, IIIc 100 64 4 94 25 61 2.5 16 89 3, IIIb 100 1 2 1 1 1 1 1 42 3, IIIc 100 107 1 69 12 9 1 41 96 4 100 113 6 108 7 79 2 76 75 Modified from Ornitz et al. (1996)....
[...]
1,994 citations
"Fibroblast growth factors, their re..." refers background in this paper
...Defining features of the FGF family are a strong affinity for heparin and HLGAGs (Burgess & Maciag 1989), as well as a central core of 140 amino acids that is highly homologous between different family members....
[...]