Fibroblast growth factors, their receptors and signaling.
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TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
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A Phase II Trial of Dovitinib in BCG-Unresponsive Urothelial Carcinoma with FGFR3 Mutations or Overexpression: Hoosier Cancer Research Network Trial HCRN 12-157.
Noah M. Hahn,Trinity J. Bivalacqua,Ashley E. Ross,George J. Netto,Alexander S. Baras,Jong Chul Park,Carolyn Chapman,Timothy A. Masterson,Michael O. Koch,Richard Bihrle,Richard S. Foster,Thomas A. Gardner,Liang Cheng,David R. Jones,Kyle McElyea,George E. Sandusky,Timothy Breen,Ziyue Liu,Costantine Albany,Marietta L. Moore,Rhoda A. Loman,Angela D. Reed,Scott A. Turner,Francine B. de Abreu,Torrey L. Gallagher,Gregory J. Tsongalis,Elizabeth R. Plimack,Richard E. Greenberg,Daniel M. Geynisman +28 more
TL;DR: Results support systemic administration as a viable approach to clinical trials in patients with NMIUC and suggest patient selection by pFGFR3 IHC alone does not enrich for response to FGFR3 kinase inhibitors in urothelial carcinoma.
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The expression of fibroblast growth factors and their receptors in Hodgkin's lymphoma
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Targets of Fibroblast Growth Factor 1 (FGF-1) and FGF-2 Signaling Involved in the Invasive and Tumorigenic Behavior of Carcinoma Cells
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FGFR4 Role in Epithelial-Mesenchymal Transition and Its Therapeutic Value in Colorectal Cancer
Alberto Peláez-García,Rodrigo Barderas,Sofia Torres,Pablo Hernández-Varas,Joaquin Teixidó,Félix Bonilla,Antonio García de Herreros,J. Ignacio Casal +7 more
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Characteristic adaptations of the extracellular matrix in dilated cardiomyopathy
Laura Louzao-Martinez,Aryan Vink,Magdalena Harakalova,Folkert W. Asselbergs,Marianne C. Verhaar,Caroline Cheng,Caroline Cheng +6 more
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References
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