Fibroblast growth factors, their receptors and signaling.
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48 citations
Cites background from "Fibroblast growth factors, their re..."
...In addition to cell proliferation which has been most widely studied, FGF signaling impacts a wide variety of phenotypic responses related to tissue homeostasis that include cell migration, adhesion, death, differentiation, and specialized functions [4,5]....
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...to confer cell and tissue specificity of FGF signaling both in respect to activating FGF [2,3] and activation of downstream intracellular pathways [4,5]....
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48 citations
Cites background from "Fibroblast growth factors, their re..."
...So far 22 FGFs in humans have been discovered, and the vast majority is acting within short range, but a few homologs have been shown to have endocrine roles in metabolic homeostasis (Kuro-o, 2008; Fukumoto, 2008; Powers et al., 2000; Ornitz and Itoh, 2001)....
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47 citations
Cites background from "Fibroblast growth factors, their re..."
...Exogenous FGF induces FGF-R phosphorylation, which may initiate various intracellular transduction pathways, such as those involving Ras/ MAP kinases, PLC-g and PI3K/Akt pathways (Johnson and Williams, 1993; Powers et al., 2000; Ong et al., 2001; Hashimoto et al., 2002)....
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47 citations
47 citations
Cites background from "Fibroblast growth factors, their re..."
...A specific role for FGFR4 is not well established in cancer, but altered expression has been documented in breast, lung, pancreatic and prostate cancers (47)....
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References
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2,433 citations
"Fibroblast growth factors, their re..." refers background in this paper
...One way these recruited target proteins may be localized to the activated receptor is through the interaction between their Src-homology 2 (SH2) domains and specific phosphotyrosine residues on the activated receptor (Pawson 1995)....
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...Phosphorylated tyrosine residues, in turn, recruit other signaling molecules to the activated receptors and propagate the signal through many possible transduction pathways (Pawson 1995)....
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2,364 citations
2,066 citations
"Fibroblast growth factors, their re..." refers background in this paper
...†From Ornitz et al. (1996), except where stated; ‡From Koga et al. (1995); §From Miralles et al. (1999); ¶From Xu et al. (1999). topologically identical to interleukin-1β (IL-1β) (Zhu et al. 1991), with which some members also share the feature of secretion by an endoplasmic reticulum…...
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...Mutation of all four cysteines to serines results in a protein with the same secondary structure and equally mitogenic for 3T3 cells as the wild-type FGF-2 (Foxet al. 1988), suggesting that the formation of disulfide bridges is not important for the secondary structure and mitogenic activity of…...
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...Ornitz et al. (1996) determined the specificity of different FGFs for different receptor isoforms by overexpressing these isoforms in Baf3 cells, which do not normally express FGFRs, and assaying for [3H]thymidine incorporation in these cells following treatment with different FGFs (see Table 2)....
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...1, IIIb 100 60 34 16 4 5 6 4 4 1, IIIc 100 104 0 102 59 55 0 1 21 2, IIIb 100 9 45 15 5 5 81 4 7 2, IIIc 100 64 4 94 25 61 2.5 16 89 3, IIIb 100 1 2 1 1 1 1 1 42 3, IIIc 100 107 1 69 12 9 1 41 96 4 100 113 6 108 7 79 2 76 75 Modified from Ornitz et al. (1996)....
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1,994 citations
"Fibroblast growth factors, their re..." refers background in this paper
...Defining features of the FGF family are a strong affinity for heparin and HLGAGs (Burgess & Maciag 1989), as well as a central core of 140 amino acids that is highly homologous between different family members....
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