Fibroblast growth factors, their receptors and signaling.
Citations
42 citations
Cites background from "Fibroblast growth factors, their re..."
...Fgfs interact with Fgf-tyrosine-kinase receptors (FgfR) to mediate the regulation of cell proliferation, migration, survival, differentiation, growth, and cell identity (Goldfarb, 1996; Ornitz et al., 1996; Powers et al., 2000)....
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...The roles of some Fgf proteins in development have been previously analyzed (for a review, see Powers et al., 2000)....
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...© 2007 Wiley-Liss, Inc. they present mitogenic and angiogenic effects in cancer progression and active migratory effects in metastasis (reviewed in Goldfarb, 1996; Powers et al., 2000; Ornitz and Itoh, 2001)....
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42 citations
42 citations
Cites background from "Fibroblast growth factors, their re..."
...Binding of bFGF to its receptor results in autophosphorylation of the receptor (Powers et al., 2000), activation, and ultimately the induction of transcription regulatory proteins (Debiais et al., 2001; Kim et al., 2003). bFGF is a constituent of the bone matrix and cultured osteoblasts produce…...
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...The cellular actions of FGFs are known to be mediated by interaction with FGFRs, a family of tyrosine kinase receptors (Powers et al., 2000)....
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42 citations
42 citations
Cites background from "Fibroblast growth factors, their re..."
...Both factors signal by membrane-associated receptors and share common mitogenic pathways including phospholipase C- and consecutive activation of protein kinase C (17,18)....
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References
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2,433 citations
"Fibroblast growth factors, their re..." refers background in this paper
...One way these recruited target proteins may be localized to the activated receptor is through the interaction between their Src-homology 2 (SH2) domains and specific phosphotyrosine residues on the activated receptor (Pawson 1995)....
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...Phosphorylated tyrosine residues, in turn, recruit other signaling molecules to the activated receptors and propagate the signal through many possible transduction pathways (Pawson 1995)....
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2,364 citations
2,066 citations
"Fibroblast growth factors, their re..." refers background in this paper
...†From Ornitz et al. (1996), except where stated; ‡From Koga et al. (1995); §From Miralles et al. (1999); ¶From Xu et al. (1999). topologically identical to interleukin-1β (IL-1β) (Zhu et al. 1991), with which some members also share the feature of secretion by an endoplasmic reticulum…...
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...Mutation of all four cysteines to serines results in a protein with the same secondary structure and equally mitogenic for 3T3 cells as the wild-type FGF-2 (Foxet al. 1988), suggesting that the formation of disulfide bridges is not important for the secondary structure and mitogenic activity of…...
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...Ornitz et al. (1996) determined the specificity of different FGFs for different receptor isoforms by overexpressing these isoforms in Baf3 cells, which do not normally express FGFRs, and assaying for [3H]thymidine incorporation in these cells following treatment with different FGFs (see Table 2)....
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...1, IIIb 100 60 34 16 4 5 6 4 4 1, IIIc 100 104 0 102 59 55 0 1 21 2, IIIb 100 9 45 15 5 5 81 4 7 2, IIIc 100 64 4 94 25 61 2.5 16 89 3, IIIb 100 1 2 1 1 1 1 1 42 3, IIIc 100 107 1 69 12 9 1 41 96 4 100 113 6 108 7 79 2 76 75 Modified from Ornitz et al. (1996)....
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1,994 citations
"Fibroblast growth factors, their re..." refers background in this paper
...Defining features of the FGF family are a strong affinity for heparin and HLGAGs (Burgess & Maciag 1989), as well as a central core of 140 amino acids that is highly homologous between different family members....
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