Fibroblast growth factors, their receptors and signaling.
Reads0
Chats0
TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
Citations
More filters
Journal ArticleDOI
Cardiac muscle cell formation after development of the linear heart tube
TL;DR: In this article, the authors used an immunohistochemical approach to determine that myocardium formation starts around embryonic day 12 in the dorsal mesocardium and the process extends downstream into the intracardiac mesenchymal tissues of the atrioventricular canal and outflow tract and upstream into the extracardiac mediastinal mesenchyme embedding the pulmonary and caval veins.
Journal ArticleDOI
Heterodimerization of FGF-receptor 1 and PDGF-receptor-α: a novel mechanism underlying the inhibitory effect of PDGF-BB on FGF-2 in human cells
Debora Faraone,Maria Simona Aguzzi,Gianluca Ragone,Katia Russo,Maurizio C. Capogrossi,Antonio Facchiano +5 more
TL;DR: Results suggest that FGF-R1/PDGF- Ralpha heterodimerization may represent a novel endogenous mechanism to modulate the action of these receptors and their ligands and to control endothelial cell function.
Journal ArticleDOI
Inhibition of α-SMA by the ectodomain of FGFR2c attenuates lung fibrosis.
Wang Ju,Yu Zhihong,Zhou Zhiyou,Huang Qin,Wang Dingding,Sun Li,Zhu Baowei,Wei Xing,He Ying,Hong An +9 more
TL;DR: The soluble ectodomain of fibroblast growth factor receptor-IIIc (sFGFR2c) is able to bind to fibro Blast growth factor ligands and block the activation of the FGF-signaling pathway and may have potential for the treatment of lung fibrosis as an F GF-2 antagonist.
Journal ArticleDOI
Sugar-coating wound repair: a review of FGF-10 and dermatan sulfate in wound healing and their potential application in burn wounds.
TL;DR: This novel therapeutic combination could be used in conjunction with some of the current therapies, but it would have the unique ability to initiate wound healing by stimulating keratinocyte epithelialization.
Journal ArticleDOI
FGFR2IIIb signaling regulates thymic epithelial differentiation.
TL;DR: Findings indicate that TE compartments are dynamically maintained and that FGF signals are involved in this process, as targeted expression by thymocytes of an fibroblast growth factor receptor‐2IIIb ligand profoundly alters the differentiation and function of thymic epithelium (TE).
References
More filters
Journal ArticleDOI
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
TL;DR: It is demonstrated that free heparin and heparan sulfate can reconstitute a low affinity receptor that is, in turn, required for the high affinity binding of bFGF.
Journal ArticleDOI
Protein modules and signalling networks
TL;DR: This work highlights conserved protein domains that act as key regulatory participants in many of these different signalling pathways in multicellular organisms.
Journal ArticleDOI
Thalidomide is an inhibitor of angiogenesis.
TL;DR: Electron microscopic examination of the corneal neovascularization of thalidomide-treated rabbits revealed specific ultrastructural changes similar to those seen in the deformed limb bud vasculature of Thalidomid-treated embryos.
Journal ArticleDOI
Receptor specificity of the fibroblast growth factor family.
David M. Ornitz,Jingsong Xu,Jennifer S. Colvin,Donald G. McEwen,Craig A. MacArthur,François Coulier,Guangxia Gao,Mitchell Goldfarb +7 more
TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.