Fibroblast growth factors, their receptors and signaling.
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"Fibroblast growth factors, their re..." refers background in this paper
...(1995) saw no direct interaction and instead proposed that, as the Tyr766 to Phe766 mutant had high levels of phosphorylated Src, the PLCγ pathway inhibits Src activity....
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...Cloning of the human FGF receptor (FGFR) genes identified the first two,fgfr-1 and fgfr-2, asflg and bek (Dionne et al. 1990), both of which were previously identified tyrosine kinase proteins (Kornbluth et al. 1988, Rutaet al. 1989)....
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222 citations
"Fibroblast growth factors, their re..." refers background in this paper
...FGF-1 has also been shown to stimulate DNA synthesis without signaling through a cell-surface FGF receptor (Wiedlocha et al. 1994), suggesting that the nuclear localization signal may allow FGF-1 to act through an intracrine mechanism....
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213 citations
"Fibroblast growth factors, their re..." refers background in this paper
...One way these recruited target proteins may be localized to the activated receptor is through the interaction between their Src-homology 2 (SH2) domains and specific phosphotyrosine residues on the activated receptor (Pawson 1995)....
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...Phosphorylated tyrosine residues, in turn, recruit other signaling molecules to the activated receptors and propagate the signal through many possible transduction pathways (Pawson 1995)....
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