Fibroblast growth factors, their receptors and signaling.
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"Fibroblast growth factors, their re..." refers background in this paper
...†From Ornitz et al. (1996), except where stated; ‡From Koga et al. (1995); §From Miralles et al. (1999); ¶From Xu et al. (1999). topologically identical to interleukin-1β (IL-1β) (Zhu et al. 1991), with which some members also share the feature of secretion by an endoplasmic reticulum…...
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183 citations
"Fibroblast growth factors, their re..." refers background in this paper
...However, mutation of Tyr766 did not affect FGFR-mediated mitogenesis, neuronal differentiation (Spivak-Kroizmanet al. 1994b), or mesoderm-induction in aXenopusanimal cap model (Muslinet al. 1994)....
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...…reticulum while DAG and calcium activate PKC. PLCγ was identified as a 150-kDa phosphoprotein associated with FGFR following ligand-dependent activation (Burgesset al. 1990), and this association is due to binding between the SH2 domain of PLCγ and Tyr766 of FGFR-1 (Mohammadi et al. 1991)....
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...(1995) saw no direct interaction and instead proposed that, as the Tyr766 to Phe766 mutant had high levels of phosphorylated Src, the PLCγ pathway inhibits Src activity....
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...There are seven tyrosine residues in the cytoplasmic tail of FGFR-1 that can be substrates for phosphorylation: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766....
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...In turn, IP3 facilitates the release of calcium stores from the endoplasmic reticulum while DAG and calcium activate PKC. PLCγ was identified as a 150-kDa phosphoprotein associated with FGFR following ligand-dependent activation (Burgesset al. 1990), and this association is due to binding between the SH2 domain of PLCγ and Tyr766 of FGFR-1 (Mohammadi et al. 1991)....
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181 citations
"Fibroblast growth factors, their re..." refers background in this paper
...(1995) saw no direct interaction and instead proposed that, as the Tyr766 to Phe766 mutant had high levels of phosphorylated Src, the PLCγ pathway inhibits Src activity....
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