Fibroblast growth factors, their receptors and signaling.
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TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
Citations
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Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.
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TL;DR: This study completes the mitogenesis-based comparison of receptor specificity of the entire FGF family under standard conditions and should help in interpreting and predicting in vivo biological activity.
References
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B A Springer,M W Pantoliano,F A Barbera,Paul L. Gunyuzlu,Leo D. Thompson,W F Herblin,Stuart A. Rosenfeld,G W Book +7 more
TL;DR: Using protein structure-based site-directed mutagenesis of basic FGF, this represents a mechanism for the fibroblast growth factor/receptor family in which FGF facilitates FGFR dimerization and subsequent signal transduction events as a monomeric ligand.
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Fgf-8, activated by proviral insertion, cooperates with the Wnt-1 transgene in murine mammary tumorigenesis.
TL;DR: Results implicate Fgf-8 as the third FGF gene found to cooperate with Wnt-1 in MMTV-induced murine mammary tumorigenesis, suggesting that FGFs and Wnts are strong collaborators in this process.
Journal ArticleDOI
Fibroblast Growth Factor Receptors (FGFRs) Localize in Different Cellular Compartments A SPLICE VARIANT OF FGFR-3 LOCALIZES TO THE NUCLEUS
TL;DR: In this paper, specific antibodies to the second immunoglobulin-like domain of fibroblast growth factor receptors (FGFRs) were raised to investigate the expression and subcellular localization of FGFR-1, -2, -3, and -4 in breast epithelial cells.
Journal ArticleDOI
Glycosylation allows cell-surface transport of an anchored secretory protein.
TL;DR: The creation and expression of a hybrid gene encoding a membrane-anchored form of rat growth hormone and results suggest that N-linked glycosylation can serve as a signal for protein transport to the cell surface.
Journal Article
Fibroblast Growth Factor 4 Transfection of MCF-7 Cells Produces Cell Lines That Are Tumorigenic and Metastatic in Ovariectomized or Tamoxifen-treated Athymic Nude Mice
Sandra W. McLeskey,J Kurebayashi,Susan F. Honig,James A. Zwiebel,Marc E. Lippman,Robert B. Dickson,Francis G. Kern +6 more
TL;DR: A possible role for fibroblast growth factors in the progression of breast tumors to an estrogen-independent, antiestrogen-resistant, metastatic phenotype is suggested and a role for paracrine factors in mixed populations of tumor cells of differing states of malignant progression is supported.