Fibroblast growth factors, their receptors and signaling.
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"Fibroblast growth factors, their re..." refers background in this paper
...First, the HLGAGs recruit FGFs to the cell surface, increasing their concentration and making activation of their receptors more thermodynamically favorable....
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116 citations
Additional excerpts
...neovascularization in the rat cornea (Gillis et al. 1999)....
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115 citations
"Fibroblast growth factors, their re..." refers background in this paper
...Larsson et al. (1999) have shown that Crk binds via its SH2 domain to Tyr of the activated FGFR....
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114 citations
"Fibroblast growth factors, their re..." refers background in this paper
...However, the portion of FGF-2 removed, while being slightly hydrophobic, does not contain a known signal sequence motif (Klagsbrun et al. 1987)....
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114 citations
"Fibroblast growth factors, their re..." refers background in this paper
...FGF-9 was originally purified from the conditioned medium of the glial cell line NMC-G1 and, based on its activity, named glia-activating factor (GAF) (Miyamotoet al. 1993)....
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...FGF-4 (hst-1/kFGF) fgf-4 was identified by the screening of human stomach tumors and samples of Kaposi’s sarcoma for genes capable of transforming 3T3 fibroblasts (Sakamotoet al. 1986, Delli Bovi & Basilico 1987)....
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...Nevertheless, FGF-9 is still efficiently secreted, suggesting that it utilizes an alternate ER-Golgi-independent pathway for secretion....
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...Initially, there were thought to be two different genes responsible for this activity, hst and the KS oncogene, but, based on homology to each other and to other fgfs, they were found to be one gene,fgf-4 (Delli Bovi et al. 1987, Yoshidaet al. 1987)....
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