Fibroblast growth factors, their receptors and signaling.
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TLDR
FGF signaling also appears to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state.Abstract:
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in common certain structural characteristics, and most of whom bind heparin avidly. Many FGFs contain signal peptides for secretion and are secreted into the extracellular environment, where theycan bind to the heparan-like glycosaminoglycans (HLGAGs) of the extracellular matrix (ECM). From this reservoir, FGFs mayact directlyon target cells, or theycan be released through digestion of the ECM or the activityof a carrier protein, a secreted FGF binding protein. FGFs bind specific receptor tyrosine kinases in the context of HLGAGs and this binding induces receptor dimerization and activation, ultimatelyresulting in the activation of various signal transduction cascades. Some FGFs are potent angiogenic factors and most playimportant roles in embry onic development and wound healing. FGF signaling also appears to playa role in tumor growth and angiogenesis, and autocrine FGF signaling maybe particularlyimportant in the progression of steroid hormone-dependent cancers to a hormone-independent state.read more
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References
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Immunohistochemical study of overexpression of fibroblast growth factor-1 (fgf-1), fgf-2, and fgf receptor-1 in human malignant salivary gland tumours
Yoshiko Myoken,Yoshinari Myoken,Tetsuji Okamoto,J. Denry Sato,Mikio Kan,Wallace L. McKeehan,Mitsuru Nakahara,Kazuaki Takada +7 more
TL;DR: It is demonstrated that malignant salivary gland tumours overexpress FGF‐1, F GF‐2, and FGFR‐1 compared with normal salivARY glands and suggested that these growth factors may play an important role in facilitating neoplastic progression in human salvary glands.
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A growth-promoting influence from the mesonephros during limb outgrowth.
Jane S. Geduspan,Michael Solursh +1 more
TL;DR: The results suggest that the influence from the mesonephros may provide some signal for limb outgrowth.
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Expression of fibroblast growth factor and FGF-receptor family genes in human myeloma cells, including lines possessing t(4;14)(q16.3;q32. 3) and FGFR3 translocation.
Takemi Otsuki,Osamu Yamada,Kenichiro Yata,Haruko Sakaguchi,Junichi Kurebayashi,N Nakazawa,M Taniwaki,Yoshihito Yawata,Ayako Ueki +8 more
TL;DR: Findings indicate that t(4;14) (q16.3;q32.3) may provide myeloma cells with a growth advantage via an autocrine mechanism between FGFR3 and FGF-4.
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Culture-induced increase in acidic and basic fibroblast growth factor activities and their association with the nuclei of vascular endothelial and smooth muscle cells.
TL;DR: The activity of acidic and basic fibroblast growth factor‐like mitogens (aFGF, bFGF) extracted from cultured bovine aorta endothelial and rat aortic smooth muscle cells was compared with that of freshly isolated cells from the same tissues to consistently find aFGF‐like activity in both cell types.