Finding the missing heritability of complex diseases
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...’’ Possible explanations include a large number of common variants with small effects, rare variants with large effects, and DNA structural variation.(2,4) We recently proposed a method of estimating the total amount of phenotypic variance captured by all SNPs on the current generation of commercial genotyping arrays and estimated that ~45% of the phenotypic variance for human height can be explained by all common SNPs....
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...For most traits, the associated SNPs from GWAS only explain a small fraction of the heritability.(2,3) There has not been any consensus on the explanation of the ‘‘missing heritability....
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