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Journal ArticleDOI

Finite element stress analysis of left ventricular mechanics in the beating dog heart

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TLDR
There may be significant regional nonhomogeneity of fiber stress in the normal left ventricle associated with regional variations in shape and fiber angle, unlike in the midventricle region that has been studied most fully.
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This article is published in Journal of Biomechanics.The article was published on 1995-10-01. It has received 334 citations till now.

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Citations
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Journal ArticleDOI

Electromechanical model of excitable tissue to study reentrant cardiac arrhythmias.

TL;DR: It is shown that tissue mechanics significantly contributes to the dynamics of electrical propagation, and that a coupled electromechanical approach should be pursued in future electrophysiological modelling studies.
Journal ArticleDOI

Theoretical impact of the injection of material into the myocardium: a finite element model simulation.

TL;DR: Simulations indicate that the addition of noncontractile material to a damaged left ventricular wall has important effects on cardiac mechanics, with potentially beneficial reduction of elevated myofiber stresses, as well as confounding changes to clinicalleft ventricular metrics.
Journal ArticleDOI

Modeling total heart function.

TL;DR: The models have established the computational framework for linking the structure and function of cardiac cells and tissue to the integrated behavior of the intact heart, but many more aspects of physiological function need to be included before significant progress can be made in understanding many disease processes.
Journal ArticleDOI

Three-dimensional analysis of regional cardiac function: a model of rabbit ventricular anatomy

TL;DR: The three-dimensional geometry and anisotropic properties of the heart give rise to nonhomogeneous distributions of stress, strain, electrical activation and repolarization, which motivate the development of coupled three- dimensional models of cardiac electromechanics and mechanoelectric feedback.
Journal ArticleDOI

Modelling cardiac mechanical properties in three dimensions

TL;DR: Current models capture some important properties of healthy and diseased myocardium including: the nonlinear interactions between the responses to different loading patterns; the influence of the laminar myofibre sheet architecture; the effects of transverse stresses developed by the myocytes; and the relationship between collagen fibre architecture and mechanical properties in healing scar tissue after myocardial infarction.
References
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Journal ArticleDOI

Hemodynamic determinants of oxygen consumption of the heart with special reference to the tension-time index.

TL;DR: The hemodynamic determinants of myocardial oxygen utilization were ascertained in the isolated, metabolically supported, nonfailing canine heart and the primary determinant was found to be the total oxygen requirement.
Book

Biomechanics: Motion, Flow, Stress, and Growth

TL;DR: In this paper, the authors describe internal deformation and forces, stress, strain, and stability of organs, strength, Trauma, and Tolerance of growth and tissue engineering, as well as Biomechanical Aspects of Growth and Tissue Engineering.
Journal ArticleDOI

Mathematical model of geometry and fibrous structure of the heart.

TL;DR: These methods provide a compact and accurate anatomic description of the ventricles suitable for use in finite element stress analysis, simulation of cardiac electrical activation, and other cardiac field modeling problems.
Journal ArticleDOI

Passive material properties of intact ventricular myocardium determined from a cylindrical model.

TL;DR: The results indicate that torsion, residual stress and material anisotropy associated with the fiber architecture all can act to reduce endocardial stress gradients in the passive left ventricle.
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