FLASH Irradiation with Proton Beams: Beam Characteristics and Their Implications for Beam Diagnostics
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TLDR
This work will review the status and proposed solutions, from the point of view of the beam definitions for FLASH and their implications for beam diagnostics, and devote particular attention to the topics of beam monitoring and control, as well as absolute dose measurements.Abstract:
FLASH irradiations use dose-rates orders of magnitude higher than commonly used in patient treatments. Such irradiations have shown interesting normal tissue sparing in cell and animal experiments, and, as such, their potential application to clinical practice is being investigated. Clinical accelerators used in proton therapy facilities can potentially provide FLASH beams; therefore, the topic is of high interest in this field. However, a clear FLASH effect has so far been observed in presence of high dose rates (>40 Gy/s), high delivered dose (tens of Gy), and very short irradiation times (<300 ms). Fulfilling these requirements poses a serious challenge to the beam diagnostics system of clinical facilities. We will review the status and proposed solutions, from the point of view of the beam definitions for FLASH and their implications for beam diagnostics. We will devote particular attention to the topics of beam monitoring and control, as well as absolute dose measurements, since finding viable solutions in these two aspects will be of utmost importance to guarantee that the technique can be adopted quickly and safely in clinical practice.read more
Citations
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The current status of preclinical proton FLASH radiation and future directions.
TL;DR: A review of the current status of proton FLASH experimental systems, including preclinical physical and biological results, is provided in this article, where the authors focus on future areas of development with a focus on the determination of the optimal parameters for maximizing the therapeutic ratio between tumor and normal tissue response.
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A new emittance selection system to maximize beam transmission for low-energy beams in cyclotron-based proton therapy facilities with gantry
Vivek Maradia,Vivek Maradia,David Meer,Damien C. Weber,Damien C. Weber,Damien C. Weber,Antony J. Lomax,Antony J. Lomax,Jacobus M. Schippers,Serena Psoroulas +9 more
TL;DR: In this paper, a collimation system, asymmetric in both beam size and divergence, was proposed to achieve symmetric emittance in beam transverse planes as required for a gantry system.
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Repurposing Proton Beam Therapy through Novel Insights into Tumour Radioresistance.
TL;DR: In this paper, the role of proton beam therapy (PBT) in addressing radioresistance, through better patient selection, and by providing an improved toxicity profile for integration with novel agents.
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Recent progress in pencil beam scanning FLASH proton therapy: a narrative review
S. Wei,Chengyu Shi,Chin Cheng Chen,Shenglan Huang,Robert H. Press,J. Isabelle Choi,Charles B. Simone,Haibo Lin,Minglei Kang +8 more
TL;DR: As PBS FLASH delivery has enabled successful biological studies using transmission beams, the further improvement in PBS Bragg peak FLASH technologies will result in more advanced treatment plans associated with potentially improved outcomes.
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Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
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TL;DR: This first FLash-RT treatment was feasible and safe with a favorable outcome both on normal skin and the tumor, and prompt to further clinical evaluation of FLASH-RT.