Journal ArticleDOI
Flavin dependent monooxygenases.
Mieke M.E. Huijbers,S. Montersino,Adrie H. Westphal,Dirk Tischler,Dirk Tischler,Willem J. H. van Berkel +5 more
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TLDR
An update of the classification of flavin-dependent monooxygenases is presented and the latest advances in the understanding of their catalytic and structural properties are summarized.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 2014-02-15. It has received 395 citations till now. The article focuses on the topics: Flavin reductase & Monooxygenase.read more
Citations
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The contributory role of gut microbiota in cardiovascular disease
TL;DR: These studies reveal that nutrient precursors, gut microbiota, and host participants along the meta-organismal pathway elucidated may serve as new targets for the prevention and treatment of CVD.
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Biocatalytic Oxidation Reactions: A Chemist's Perspective
JiaJia Dong,Elena Fernández-Fueyo,Frank Hollmann,Caroline E. Paul,Milja Pesic,Sandy Schmidt,Yonghua Wang,Sabry H. H. Younes,Wuyuan Zhang +8 more
TL;DR: The most important recent developments in the field of biocatalytic oxidation chemistry are critically summarised and the most pressing bottlenecks as well as promising solutions are identified.
Journal ArticleDOI
Same Substrate, Many Reactions: Oxygen Activation in Flavoenzymes
TL;DR: The state of the art on a key area of research in flavin enzymology: the molecular basis for the activation of O2 by flavin-dependent oxidases and monooxygenases is summarized.
Journal ArticleDOI
Oxidative Cyclization in Natural Product Biosynthesis
TL;DR: This Review examines the different strategies used by nature to create new intra(inter)molecular bonds via redox chemistry, with an emphasis on the former.
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Development of Halogenase Enzymes for Use in Synthesis
Jonathan Latham,Eileen Brandenburger,Sarah A. Shepherd,Binuraj R. K. Menon,Jason Micklefield +4 more
TL;DR: Advances in developing halogenases forBiocatalysis, potential untapped sources of such biocatalysts and how further optimization of these enzymes is required to achieve the goal of industrial scale biohalogenation are discussed.
References
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Kynurenines in the mammalian brain: when physiology meets pathology
TL;DR: With recently developed pharmacological agents, it is now possible to restore metabolic equilibrium and envisage novel therapeutic interventions on the basis of the kynurenine pathway.
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Activation of molecular oxygen by flavins and flavoproteins.
TL;DR: Clearly the reactivity of the reduced flavin with 0, is modulated by the protein environment in which i t is located, both in terms of rates and products of the reaction.
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Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1.
Dmitri V. Mavrodi,Robert F. Bonsall,Shannon M. Delaney,Marilyn Soule,Greg Phillips,Linda S. Thomashow +5 more
TL;DR: The results suggest that there is a complex pyocyanin biosynthetic pathway in P. aeruginosa consisting of two core loci responsible for synthesis of PCA and three additional genes encoding unique enzymes involved in the conversion ofPCA to pyochenin, 1-hydroxyphenazine, and phenazine-1-carboxamide.
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Flavoprotein monooxygenases, a diverse class of oxidative biocatalysts.
TL;DR: An inventory of known flavoprotein monooxygenases belonging to these different enzyme subclasses is provided and the biocatalytic potential of a selected number of flavop protein monooxyGENases is highlighted.
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Auxin biosynthesis: a simple two-step pathway converts tryptophan to indole-3-acetic acid in plants.
TL;DR: The first complete auxin biosynthesis pathway that converts tryptophan (Trp) to IAA in plants is established and plays an essential role in many developmental processes.