FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
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Cites background from "FMRP stalls ribosomal translocation..."
...We also know that the rate of translation is not constant across a message, and translation pauses can regulate synthesis (Darnell et al., 2011; Morris and Geballe, 2000), folding (Kimchi-Sarfaty et al., 2007; Zhang et al., 2009), and localization of a protein (Mariappan et al., 2010) or mRNA…...
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Cites background from "FMRP stalls ribosomal translocation..."
...This has suggested overlaying recent understanding of FXS biology onto candidate ASD genes (Darnell et al., 2011)....
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...We observe an unusual coincidence between the list of genes with disruptive de novo mutations in children with autism and the list of 842 gene products associated with FMRP (Darnell et al., 2011), itself a target of mutation in 2% of children with ASD....
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...Mediators of Neuroplasticity inCognitive andBehavioral Disorders FMRP may act as one component of a central regulator of synaptic plasticity, among others such as TSC2 (Darnell et al., 2011; Auerbach et al., 2011)....
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...Significant overlap of the 842 FMRP-associated genes with autism candidate genes has been previously suggested (Darnell et al., 2011)....
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...Other de novo mutations of interest were a 4 bp deletion in DST (encoding the basement membrane glycoprotein dystonin), which is associated with FMRP (Darnell et al., 2011) and produces a neurodegeneration phenotype when inactivated in themouse, and a nonsensemutation in ANK2 (an ankyrin protein involved in synaptic stability [Koch et al....
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References
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"FMRP stalls ribosomal translocation..." refers methods in this paper
...False discovery rate (FDR) was estimated by the Benjamini-Hochberg method (Benjamini and Hochberg, 1995)....
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...p-values reported for this study were corrected using the Benjamini-Hochberg approach (Benjamini and Hochberg, 1995)....
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31,015 citations
"FMRP stalls ribosomal translocation..." refers methods in this paper
...We used the DAVID Bioinformatics database to analyze the gene ontology (GO) terms assigned to them....
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...Gene Ontology Analysis The enrichment of gene ontology (GO) terms in FMRP targets was analyzed using the online tool DAVID (Huang et al., 2009; Dennis et al., 2003)....
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...GO functional category enrichment was analyzed using DAVID 6.7 software....
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"FMRP stalls ribosomal translocation..." refers methods in this paper
...Differential expression between wild-type or FMRP knockout brains was evaluated by the naive Bayes method, using total RNA level or normalized polysome RNA level (Smyth, 2004)....
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