fNIRS Study of Walking and Walking While Talking in Young and Old Individuals
Roee Holtzer,Roee Holtzer,Jeannette R. Mahoney,Jeannette R. Mahoney,Meltem Izzetoglu,Kurtulus Izzetoglu,Banu Onaral,Joe Verghese +7 more
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TLDR
This study provided the first evidence that oxygenation levels are increased in the PFC during WWT compared with NW in young and old individuals, and was modified by age suggesting that older adults may under-utilize the P FC in attention-demanding locomotion tasks.Abstract:
Background. Evidence suggests that gait is influenced by higher order cognitive and cortical control mechanisms. However, less is known about the functional correlates of cortical control of gait. Methods. Using functional near-infrared spectroscopy, the current study was designed to evaluate whether increased activations in the prefrontal cortex (PFC) were detected in walking while talking (WWT) compared with normal pace walking (NW) in 11 young and 11 old participants. Specifically, the following two hypotheses were evaluated: (a ) Activation in the PFC would be increased in WWT compared with NW. (b) The increase in activation in the PFC during WWT as compared with NW would be greater in young than in old participants. Results. Separate linear mixed effects models with age as the two-level between-subject factor, walking condition (NW vs WWT) as the two-level repeated within-subject factor, and HbO2 levels in each of the 16 functional near-infrared spectroscopy channels as the dependent measure revealed significant task effects in 14 channels, indicating a robust bi lateral increased activation in the PFC in WWT compared with NW. Furthermore, the group-by-task interaction was significant in 11 channels with young participants showing greater WWT-related increase in HbO2 levels compared with the old participants.read more
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A wearable multi-channel fNIRS system for brain imaging in freely moving subjects.
Sophie K. Piper,Arne Krueger,Stefan Koch,Jan Mehnert,Christina Habermehl,Jens Steinbrink,Hellmuth Obrig,Christoph H. Schmitz +7 more
TL;DR: This is the first demonstration of functional NIRS brain imaging during an outdoor activity in a real life situation in humans and provides quantitative guidelines for taking condition-dependent signal quality into account to allow the comparison of data across various levels of physical exercise.
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Automaticity of walking: functional significance, mechanisms, measurement and rehabilitation strategies.
David J. Clark,David J. Clark +1 more
TL;DR: The objective of this article is to advance the science of automaticity of walking by consolidating evidence and identifying gaps in knowledge regarding: (a) functional significance ofautomaticity; (b) neurophysiology of automaticITY; (c) measurement of automaticities; (d) mechanistic factors that compromise automaticity; and (e) strategies for rehabilitation of automaticality.
Journal ArticleDOI
Neuroimaging of Mobility in Aging: A Targeted Review
Roee Holtzer,Roee Holtzer,Noah Epstein,Jeannette R. Mahoney,Meltem Izzetoglu,Helena M. Blumen +5 more
TL;DR: A targeted review of neuroimaging studies of mobility in aging shows that activation patterns in the cerebellum, basal ganglia, parietal and frontal cortices were related to mobility.
Journal ArticleDOI
Aging, the Central Nervous System, and Mobility
Andrea L. Rosso,Stephanie A. Studenski,Wen G. Chen,Howard J. Aizenstein,Neil B. Alexander,David A. Bennett,Sandra E. Black,Richard Camicioli,Michelle C. Carlson,Luigi Ferrucci,Jack M. Guralnik,Jeffrey M. Hausdorff,Jeffrey M. Hausdorff,Jeffrey Kaye,Lenore J. Launer,Lewis A. Lipsitz,Joe Verghese,Caterina Rosano +17 more
TL;DR: There is a need for new approaches to training clinicians and investigators, which integrate concepts and methodologies from individual disciplines, focus on emerging methodologies, and prepare investigators to assess complex, multisystem associations.
Journal ArticleDOI
Increased frontal brain activation during walking while dual tasking: an fNIRS study in healthy young adults
Anat Mirelman,Inbal Maidan,Inbal Maidan,Hagar Bernad-Elazari,Freek Nieuwhof,Freek Nieuwhof,Miriam F. Reelick,Nir Giladi,Nir Giladi,Jeffrey M. Hausdorff +9 more
TL;DR: This study provides direct evidence that dual tasking during walking is associated with frontal brain activation in healthy young adults and changes observed are apparently not a response to the verbalization of words and are related to the cognitive load during gait.
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