Focus on genetic and epigenetic events of colorectal cancer pathogenesis: implications for molecular diagnosis
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Cites background from "Focus on genetic and epigenetic eve..."
..., [127,147–161]) or have been subject of systematic reviews and meta-analysis (e....
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"Focus on genetic and epigenetic eve..." refers background or methods in this paper
...18q called “deleted in colorectal carcinoma” gene (DCC) [12]....
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...This sequence occurs in 60 % of CRC cases and generally the activation of an oncogene or inactivation of a oncosuppressor gene, involved in this sequence, is associated with clinicopathological tumor features (Table 2) [12]....
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...Up to 70 % of CRC have been shown to carry LOH at chromosome 18q called “deleted in colorectal carcinoma” gene (DCC) [12]....
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...LOH at chromosome 18q seems caused adenoma progression in CRC tumorigenesis, since genes on this chromosome includes over DCC even SMAD2 and SMAD4 [21]....
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...Mutations of the DCC gene are also found in 50 % of advanced adenomas of the colon [12]....
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