Journal ArticleDOI
Food allergy–related quality of life after double-blind, placebo-controlled food challenges in adults, adolescents, and children
Jantina L. van der Velde,Bertine M. J. Flokstra-de Blok,Hans de Groot,Joanne N.G. Oude-Elberink,Marjan Kerkhof,Eric J. Duiverman,Anthony E.J. Dubois +6 more
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TLDR
HRQL scores improved after a DBPCFC, with greater improvements in HRQL scores after a negative outcome than a positive outcome (food allergy confirmed), demonstrating responsiveness of the FAQLQs.Citations
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Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment
TL;DR: Advances and updates in the epidemiology, pathogenesis, diagnosis, and treatment of food allergy over the past 3 years are focused on, with incorporation of extensively heated forms of milk and egg into the diets of children who tolerate these foods represents a significant shift in clinical approach.
Journal ArticleDOI
Can we identify patients at risk of life-threatening allergic reactions to food?
Paul Turner,Joseph L. Baumert,Kirsten Beyer,Robert J. Boyle,C. H. Chan,Andrew Clark,René W.R. Crevel,Audrey DunnGalvin,Montserrat Fernandez-Rivas,M. H. Gowland,Linus Grabenhenrich,S. Hardy,Geert F. Houben,J. O'b. Hourihane,Antonella Muraro,Lars K. Poulsen,Katarzyna Pyrz,Benjamin C. Remington,Sabine Schnadt,R. van Ree,Carina Venter,Carina Venter,Margitta Worm,E. N. C. Mills,Graham Roberts,Graham Roberts,Barbara K. Ballmer-Weber +26 more
TL;DR: It is important to consider severity and sensitivity as separate factors, as a highly sensitive individual will not necessarily experience severe symptoms during an allergic reaction, and the knowledge gaps that need to be addressed are identified.
Journal ArticleDOI
Long-term clinical and immunological effects of probiotic and peanut oral immunotherapy after treatment cessation: 4-year follow-up of a randomised, double-blind, placebo-controlled trial
Kuang-Chih Hsiao,Kuang-Chih Hsiao,Anne-Louise Ponsonby,Christine Axelrad,Sigrid Pitkin,Mimi L.K. Tang,Mimi L.K. Tang,Wesley Burks,Susan Donath,Francesca Orsini,Dean Tey,Marnie Robinson,Ee Lyn Su +12 more
TL;DR: Long-term outcomes in participants who completed a randomised, double-blind, placebo-controlled trial of combined probiotic and peanut oral immunotherapy (PPOIT), which was previously shown to induce desensitisation and 2-week sustained unresponsiveness, are assessed.
Journal ArticleDOI
Quality of Life Among Food Allergic Patients and Their Caregivers
TL;DR: This review summarizes progress made studying relationships between food allergy and quality of life (QOL) with an emphasis on recent work in the field, and suggests that undergoing oral food challenge to confirmFood allergy and oral immunotherapy to treat food allergy may each improve FAQOL among both patients and their caregivers.
Journal ArticleDOI
Conducting an Oral Food Challenge: An Update to the 2009 Adverse Reactions to Foods Committee Work Group Report
J. Andrew Bird,Stephanie A. Leonard,Stephanie A. Leonard,Marion Groetch,Amal Assa'ad,Antonella Cianferoni,April Clark,Maria Crain,Tracy Fausnight,David Fleischer,David Fleischer,Todd D. Green,Matthew Greenhawt,Matthew Greenhawt,Linda Herbert,Bruce J. Lanser,Irene Mikhail,S. Shahzad Mustafa,Sally Noone,Christopher Parrish,Pooja Varshney,B.J. Vlieg-Boerstra,Michael C. Young,Scott H. Sicherer,Anna Nowak-Wegrzyn +24 more
TL;DR: The intention of this document was to supplement the previous publication with additional focus on safety, treatment of IgE-mediated allergic reactions, guidance for challenges in infants and adults, psychosocial considerations for children and families participating in an oral food challenge.
References
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Journal ArticleDOI
Interpretation of changes in health-related quality of life the remarkable universality of half a standard deviation
TL;DR: In most circumstances, the threshold of discrimination for changes in health-related quality of life for chronic diseases appears to be approximately half a SD, which research in psychology has shown is approximately 1 part in 7.
Journal ArticleDOI
Determining a minimal important change in a disease-specific quality of life questionnaire
TL;DR: The observation that the minimal important difference is consistent across domains and for both improvement and deterioration will facilitate interpretation of results of studies examining quality of life.
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Recommended methods for determining responsiveness and minimally important differences for patient-reported outcomes.
TL;DR: It is recommended that the MID is based primarily on relevant patient-based and clinical anchors, with clinical trial experience used to further inform understanding of MID.
Journal ArticleDOI
Reproducibility and responsiveness of health status measures. Statistics and strategies for evaluation.
TL;DR: Using data from a clinical trial of therapy for back pain, it is shown that reproducibility should generally be quantified with the intraclass correlation coefficient rather than the more common Pearson r.r. coefficient, and that reproduction by retest at one-to-two week intervals may result in more realistic estimates of the variability to be observed among control subjects in a longitudinal study.
Journal ArticleDOI
Methods to explain the clinical significance of health status measures.
TL;DR: One can classify ways to establish the interpretability of quality-of-life measures as anchor based or distribution based, which relies on an independent standard or anchor that is itself interpretable and at least moderately correlated with the instrument being explored.
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