Fork sensing and strand switching control antagonistic activities of RecQ helicases
Citations
19 citations
18 citations
Cites background from "Fork sensing and strand switching c..."
...Strandswitching during unwinding has been proposed for different DNA helicases as a mechanism that leads to rezipping of the opened dsDNA (7, 11, 50)....
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...For example, strand-switching during unwinding, with the helicase being able to jump to the opposite ssDNA strand and translocate back, has been proposed for multiple helicases (7, 11, 50, 55), including Pif1 (47)....
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17 citations
Cites background from "Fork sensing and strand switching c..."
...As the enzyme passes the apex, the force applied by the closing fork induces the enzyme to switch strands reverting into an unwinding mode.(58) The rate of DNA unwinding by helicases has also been studied as a function of the local AT (or GC) content of the hairpin....
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14 citations
Cites background from "Fork sensing and strand switching c..."
...While both show a highly repetitive DNA helicase function, AtRECQ2 preferentially unwinds DNA but AtRECQ3 predominantly rewinds the DNA after short unwinding activity [34]....
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14 citations
Additional excerpts
...Slippage has been observed with other helicases, however, it appears to result from different causes (Klaue et al., 2013; Lee et al., 2014; Manosas, Spiering, Ding, Croquette, & Benkovic, 2012; Myong, Bruno, Pyle, & Ha, 2007; Myong, Rasnik, Joo, Lohman, & Ha, 2005; Qi, Pugh, Spies, & Chemla, 2013;…...
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References
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