Fork sensing and strand switching control antagonistic activities of RecQ helicases
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Cites background from "Fork sensing and strand switching c..."
...Other studies with magnetic tweezers have shown that human WRN and AtRecQ2 reiteratively unwind DNA hairpins containing a stem region of ∼40–50 bp (9,10)....
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...In one model, human BLM and AtRECQ2 switch strands for rewinding (5,10), whereas in another, human and chicken WRN slide back along the translocated strand (9,11), leaving the exact molecular mechanism of DNA rewinding to be elucidated....
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...Human WRN and its Arabidopsis thaliana homolog RECQ2 (AtRECQ2) also reiteratively unwind DNA hairpins (9,10), but the unwinding lengths have not been determined for these proteins....
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...A study of AtRECQ2, a WRN homolog, also proposed the ‘strandswitching and sliding back’ mode (10)....
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6 citations
Additional excerpts
...It was prepared as previously described [21]....
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5 citations
Cites background from "Fork sensing and strand switching c..."
...Such backward movement is often observed when helicases fully unwind DNA hairpins because ds/ssDNA junctions to which helicases are stably anchored disappears (45)....
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...This behavior is similar to that of RecQ helicases that continue unwinding, regressing back and resuming (37,45)....
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4 citations
Additional excerpts
...nontranslocating strands simultaneously [150]....
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References
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