Journal ArticleDOI
Formulation and optimization of intranasal nanolipid carriers of pioglitazone for the repurposing in Alzheimer's disease using Box-Behnken design.
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TLDR
The formulation was observed to improve the nasal permeability of PIO ex-vivo significantly and Storage stability studies performed has confirmed the stability of NLCs at 4 °C and 25’°C.Abstract:
Growing evidence suggest that Alzheimer’s disease (AD), the most common cause of dementia among the elderly is a metabolic disorder associated with impaired brain insulin signaling. Hence, the diab...read more
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Recent strategies and advances in the fabrication of nano lipid carriers and their application towards brain targeting
Mukta Agrawal,Swarnlata Saraf,Shailendra Saraf,Sunil Kumar Dubey,Anu Puri,Ravish J. Patel,Ajazuddin,V. Ravichandiran,Upadhyayula Suryanarayana Murty,Amit Alexander +9 more
TL;DR: The role and application of NLC is described in detail, along with its different fabrication techniques and associated limitations, for brain targeting of bioactives with particular reference to its surface modifications, formulations aspects, pharmacokinetic behavior and efficacy towards the treatment of various neurological disorders.
Journal ArticleDOI
Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies.
Cláudia Pina Costa,João Nuno Moreira,José Manuel Sousa Lobo,Ana Catarina Silva,Ana Catarina Silva +4 more
TL;DR: Although the exact mechanism of drug transport from the nose to the brain is not fully understood and its effectiveness in humans is unclear, it appears that the intranasal route together with the use of NLCs, SLNs or NEs is advantageous for targeting drugs to thebrain.
Journal ArticleDOI
Nano Carrier Drug Delivery Systems for the Treatment of Neuropsychiatric Disorders: Advantages and Limitations.
Yana Zorkina,Olga Abramova,V. M. Ushakova,Anna Morozova,E. A. Zubkov,M P Valikhov,P. A. Mel’nikov,Alexander G. Majouga,Vladimir P. Chekhonin +8 more
TL;DR: N nanoparticles can substantially improve the drug delivery as its implication can increase BBB permeability, the pharmacodynamics and bioavailability of applied drugs, thereby enabling nanotechnology to overcome the limitations of existing pharmacotherapy of psychiatric disorders.
Journal ArticleDOI
Double optimization of rivastigmine-loaded Nanostructured Lipid Carriers (NLC) for nose-to-brain delivery using the Quality by Design (QbD) approach: formulation variables and instrumental parameters
Sara C. Cunha,Cláudia Pina Costa,Joana A. Loureiro,Jorge Alves,Andreia F. Peixoto,Ben Forbes,José Manuel Sousa Lobo,Ana Catarina Silva,Ana Catarina Silva +8 more
TL;DR: A double optimization of a rivastigmine-loaded NLC formulation for direct drug delivery from the nose to the brain using the quality by design (QbD) approach was performed, whereby the quality target product profile (QTPP) was the requisite for nose to brain delivery.
Journal ArticleDOI
Nanotherapeutics for Nose-to-Brain Drug Delivery: An Approach to Bypass the Blood Brain Barrier
David Lee,Tamara Minko +1 more
TL;DR: In this paper, a review describes mechanisms of nose-to-brain drug delivery and discusses recent advances in this area with especial emphasis on nanotechnology-based approaches, which allows the direct transport of therapeutic molecules by bypassing the blood-brain barrier and increases drug concentration in the brain.
References
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Journal ArticleDOI
Diffusion of Univalent Ions Across the Lamellae of Swollen Phospholipids
TL;DR: It is found that as the surface charge of the lipid lamellae is increased, the amount of cation per μmle of lipid increases, and the phospholipid liquid crystalline structures appear to “bind” or “capture” cations.
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Intranasal delivery to the central nervous system: Mechanisms and experimental considerations
TL;DR: This review focuses on the current understanding of the mechanisms underlying intranasal delivery to the central nervous system involving the olfactory and trigeminal nerves, the vasculature, the cerebrospinal fluid, and the lymphatic system.
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Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed
TL;DR: The term “type 3 diabetes” accurately reflects the fact that AD represents a form of diabetes that selectively involves the brain and has molecular and biochemical features that overlap with both type 1 diabetes mellitus and T2DM.
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Solid lipid nanoparticles: a modern formulation approach in drug delivery system.
TL;DR: A broad treatment of solid lipid nanoparticles is presented discussing their advantages, limitations and their possible remedies, as well as different types of nanocarriers which were based on solid lipid like solid cholesterol nanoparticles, nanostructured lipid carriers, lipid drug conjugates are discussed.
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Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease
TL;DR: Intranasal delivery provides a practical, non-invasive method of bypassing the blood-brain barrier to deliver therapeutic agents to the brain and spinal cord, and can revolutionize the treatment of Alzheimer's disease, stroke, and other brain disorders.