Four decades of structure determination by mass spectrometry: from alkaloids to heparin.
01 Nov 2002-Journal of the American Society for Mass Spectrometry (No longer published by Elsevier)-Vol. 13, Iss: 11, pp 1254-1272
TL;DR: A new concept of the ionization of highly acidic compounds as the protonated complexes with basic peptides, which allows the accurate determination of the molecular weights of the former, a highly sensitive method for the sequencing of heparin fragments and related sulfated glycosaminoglycans was developed more recently.
About: This article is published in Journal of the American Society for Mass Spectrometry.The article was published on 2002-11-01 and is currently open access. It has received 55 citations till now. The article focuses on the topics: Mass spectrometry & Fast atom bombardment.
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TL;DR: This review is the second update of the original review on the application of MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and shows a steady annual increase at the expense of older techniques such as FAB.
Abstract: This review describes the use of matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for the analysis of carbohydrates and glycoconjugates and continues coverage of the field from the previous review published in 1999 (D J Harvey, Matrix-assisted laser desorption/ionization mass spectrometry of carbohydrates, 1999, Mass Spectrom Rev, 18:349-451) for the period 1999-2000 As MALDI mass spectrometry is acquiring the status of a mature technique in this field, there has been a greater emphasis on applications rather than to method development as opposed to the previous review The present review covers applications to plant-derived carbohydrates, N- and O-linked glycans from glycoproteins, glycated proteins, mucins, glycosaminoglycans, bacterial glycolipids, glycosphingolipids, glycoglycerolipids and related compounds, and glycosides Applications of MALDI mass spectrometry to the study of enzymes acting on carbohydrates (glycosyltransferases and glycosidases) and to the synthesis of carbohydrates, are also covered
172 citations
TL;DR: This work states that complete characterization of the protein primary structure often requires determination of theprotein sequence by mass spectrometry with minimal assistance from genomic data - de novo protein sequencing.
151 citations
Cites background from "Four decades of structure determina..."
...De novo protein sequencing by MS dates back more than 30 years [5,6,7 ], first in combination with Edman degradation and then on its own....
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TL;DR: The rapid development of mass spectrometric technologies applied to protein research has catalyzed entirely new experimental approaches and opened up new types of biological questions to experimentation, culminating in the field of proteomics.
122 citations
Cites methods from "Four decades of structure determina..."
...The emerging mass spectrometric methods to sequence peptides pioneered by Biemann and co-workers, recounted in detail in Biemann, 2002 [7], while promising, were initially not of comparable sensitivity and generality to the Edman degradation....
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Patent•
18 Oct 2001TL;DR: In this article, the authors proposed a method for delivering polysaccharides by a pulmonary route to achieve local and systemic therapeutic effects, where the polysacchides may be formulated or unformulated and in some instances have an extremely fast absorption rate.
Abstract: The invention relates to methods for delivering polysaccharides by a pulmonary route to achieve local and systemic therapeutic effects. The polysaccharides may be formulated or unformulated and in some instances have an extremely fast absorption rate.
83 citations
TL;DR: It is shown how mass spectrometry has expanded from a tool for studying atomic structure and characterizing small molecules to its current incarnation as the most powerful technique for analyzing proteomes.
Abstract: Long before mass spectrometry became an important tool for cell biology, it was yielding scientific insights in physics and chemistry. Here is a brief history of how the technology has expanded from a tool for studying atomic structure and characterizing small molecules to its current incarnation as the most powerful technique for analyzing proteomes.
78 citations
References
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TL;DR: In the following, the first results on ultraviolet laser desorption (UVLD) of bioorganic compounds in the mass range above 10000 daltons are reported.
Abstract: In the following, the first results on ultraviolet laser desorption (UVLD) of bioorganic compounds in the mass range above 10000 daltons are reported. Strong molecular ion signals were registered by use of an organic matrix with strong absorption at the wavelength used for controlled energy deposition and soft desorption (7)
5,590 citations
"Four decades of structure determina..." refers background in this paper
...In the same year, Hillenkamp and Karas developed matrix assisted laser desorption ionization (MALDI), also capable of ionizing intact proteins [50]....
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Book•
01 Jun 1972
TL;DR: The chemistry and biology of Rocaglamides and related derivatives from Aglaia species (Meliacease) are discussed in detail in a recent paper by.
Abstract: S. S. Ebada, N. Lajkiewicz, J. A. Porco Jr., M. Lin-Weber, and P. Proksch: Chemistry and biology of Rocaglamides (=Flavaglines) and related derivatives from Aglaia species (Meliacease). - M. A. R. C. Bulusu, K. Baumann, and A. Stuetz: Chemistry of the immunomodulatory macrolides ascomycin and related analogues. - R. I. Misico, V. Nicotra, J. C. Oberti, G. Barboza, R. R. Gil, and G. Burton: Withanolides and related steroids.
2,115 citations
TL;DR: A method for obtaining high-quality mass spectra of molecules which previously were difficult or impossible to study by ionisation methods is described in this paper, where a new method is proposed to obtain high quality mass spectras of molecules.
Abstract: A new method for obtaining high-quality mass spectra of molecules which previously were difficult or impossible to study by ionisation methods is described
817 citations
"Four decades of structure determina..." refers background in this paper
...The late Michael Barber had discovered the ionization of comparatively large, polar molecules by “fast atom bombardment” (FAB) [ 42 ]....
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531 citations