Frailty and cancer: Implications for oncology surgery, medical oncology, and radiation oncology.
Cecilia G. Ethun,Mehmet Asim Bilen,Ashesh B. Jani,Shishir K. Maithel,Kenneth Ogan,Viraj A. Master +5 more
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TLDR
The concept of frailty has become increasingly recognized as one of the most important issues in health care and health outcomes and is of particular importance in patients with cancer who are receiving treatment with surgery, chemotherapy, and radiotherapy as discussed by the authors.Abstract:
Answer questions and earn CME/CNE The concept of frailty has become increasingly recognized as one of the most important issues in health care and health outcomes and is of particular importance in patients with cancer who are receiving treatment with surgery, chemotherapy, and radiotherapy. Because both cancer itself, as well as the therapies offered, can be significant additional stressors that challenge a patient's physiologic reserve, the incidence of frailty in older patients with cancer is especially high-it is estimated that over one-half of older patients with cancer have frailty or prefrailty. Defining frailty can be challenging, however. Put simply, frailty is a state of extreme vulnerability to stressors that leads to adverse health outcomes. In reality, frailty is a complex, multidimensional, and cyclical state of diminished physiologic reserve that results in decreased resiliency and adaptive capacity and increased vulnerability to stressors. In addition, over 70 different measures of frailty have been proposed. Still, it has been demonstrated that frail patients are at increased risk of postoperative complications, chemotherapy intolerance, disease progression, and death. Although international standardization of frailty cutoff points are needed, continued efforts by oncology physicians and surgeons to identify frailty and promote multidisciplinary decision making will help to develop more individualized management strategies and optimize care for patients with cancer. CA Cancer J Clin 2017;67:362-377. © 2017 American Cancer Society.read more
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Sarcopenia and Postoperative Complication Risk in Gastrointestinal Surgical Oncology: A Meta-analysis.
Casper Simonsen,Pieter de Heer,Eik Bjerre,Charlotte Suetta,Pernille Hojman,Bente Klarlund Pedersen,Lars Bo Svendsen,Jesper Christensen +7 more
TL;DR: Sarcopenia was associated with an increased risk of complications after gastrointestinal tumor resection, but lack of methodological consensus hampers the interpretation and clinical utilization of these findings.
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Frailty syndrome: implications and challenges for health care policy.
TL;DR: Based on currently available evidence, multi-domain intervention trials, including exercise component, especially multicomponent exercise, which includes resistance training, seem to be promising and further understanding of interventions to reverse frailty, and education/training of health care professionals should also be considered.
Journal ArticleDOI
Frailty and the management of hematologic malignancies.
Gregory A. Abel,Heidi D. Klepin +1 more
TL;DR: In this paper, the authors defined frailty and its relevance for patients with hematologic malignancy and proposed elements of a new research agenda for geriatric hematology: the exchange of age limits for rigorous frailty screening, development of disease-specific measures, and inclusion of functional and patient-reported outcomes alongside survival.
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Irradiated tumor cell-derived microparticles mediate tumor eradication via cell killing and immune reprogramming.
Chao Wan,Yajie Sun,Tian Yu,Lisen Lu,Xiaomeng Dai,Jingshu Meng,Jing Huang,Qianyuan He,Bian Wu,Zhanjie Zhang,Ke Jiang,Desheng Hu,Gang Wu,Jonathan F. Lovell,Honglin Jin,Kunyu Yang +15 more
TL;DR: It is suggested that the RIBE is predominantly mediated by irradiated tumor cell–released microparticles (RT-MPs), which induce broad antitumor effects and cause immunogenic death mainly through ferroptosis.
Journal ArticleDOI
Frailty index and all-cause and cause-specific mortality in Chinese adults: a prospective cohort study.
Junning Fan,Canqing Yu,Yu Guo,Zheng Bian,Z J Sun,Ling Yang,Yiping Chen,Huaidong Du,Zhongxiao Li,Yulong Lei,Dianjianyi Sun,Robert Clarke,Junshi Chen,Zhengming Chen,Jun Lv,Liming Li +15 more
TL;DR: A Cox proportional hazards model was used to estimate the associations between the frailty index and all-cause and cause-specific mortality in Chinese adults aged 30–79 years, adjusting for chronological age, education, and lifestyle factors.
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