Free Radicals in Biological Systems

Inside-outside transitions of phospholipids in vesicle membranes

This review shows how the basic kinetics of lipid oxidation can be simplified for application to the study of food deterioration. The physical and chemical factors that control oxidation are examined and analyzed in terms of food structure and composition. Studies of oxidation of several food items are examined in light of these kinetics and mechanisms.

Kinetics of lipid oxidation in foods

We review gases that can affect oxidative stress and that themselves may be radicals. We discuss O2 toxicity, invoking superoxide, hydrogen peroxide, and the hydroxyl radical. We also discuss super...

https://www.physiology.org/doi/pdf/10.1152/ajpregu.00614.2005

Free radical biology and medicine: it's a gas, man!

Human platelets have been separated into two extreme density populations by centrifugation in specific density media. A large-heavy platelet population with specific gravity > 1.055 and a light-small population with specific gravity < 1.046 were obtained, each representing approximately 15-20% of the total population volume. The average volume per platelet of the separated large-heavy and light-small platelet populations was 12 and 5 mu(3) respectively. When data are expressed per milliliter platelets or per gram wet weight, the large-heavy platelet population had a 2-fold greater glycogen content, 1.3-fold greater orthophosphate content, 1.3-fold greater total adenine nucleotide content, 4.2-fold greater rate of glycogenolysis, 2.6-fold greater rate of glycolysis, 2.9-fold greater rate of protein synthesis, and 5.7-fold greater rate of glycogen synthesis. Significant differences were not obtained with respect to total lipid content or total lipid synthesis. The large-heavy platelet had a 2.5-fold greater resistance to osmotic shock as measured by adenosine triphosphate (ATP) or adenosine diphosphate (ADP) release. These data, as well as diisopropyl fluorophosphate (DFP(32)) survival curves in rabbits, indicate that large-heavy platelets have a greater metabolic potential and suggest that they may be the young platelets which progress with age to light-small platelets with a diminished metabolic potential.

/pdf/heterogeneity-of-human-platelets-i-metabolic-and-kinetic-4e9uzprtf5.pdf

Free Radicals in Biological Systems

Citations

Inside-outside transitions of phospholipids in vesicle membranes

Kinetics of lipid oxidation in foods

Free radical biology and medicine: it's a gas, man!

Heterogeneity of human Platelets: I. Metabolic and kinetic evidence suggestive of young and old platelets

CHAPTER 2 – Free Radical Mechanisms of Lipid Damage and Consequences for Cellular Membranes

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