Frequent Hemodialysis Network (FHN) randomized trials: study design.
Rita S. Suri,Amit X. Garg,Glenn M. Chertow,Nathan W. Levin,Michael V. Rocco,Tom Greene,Gerald J. Beck,Jennifer J. Gassman,Paul W. Eggers,Robert A. Star,Daniel B. Ornt,Alan S Kliger +11 more
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TLDR
The Frequent Hemodialysis Network Trials Group is conducting two multicenter randomized trials of 250 subjects each, comparing conventional three times weekly HD with (1) in-center daily HD and (2) home nocturnal HD, during which feasibility of randomization, ability to deliver the interventions, and adherence will be evaluated.About:
This article is published in Kidney International.The article was published on 2007-02-02 and is currently open access. It has received 186 citations till now. The article focuses on the topics: Randomized controlled trial.read more
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In-center hemodialysis six times per week versus three times per week.
Glenn M. Chertow,Nathan W. Levin,Gerald J. Beck,Thomas A. Depner,Paul W. Eggers,Jennifer J. Gassman,Irina Gorodetskaya,Tom Greene,Sam James,Brett Larive,Robert M. Lindsay,Ravindra L. Mehta,Brent W. Miller,Daniel B. Ornt,Sanjay Rajagopalan,Anjay Rastogi,Michael V. Rocco,Brigitte Schiller,Olga Sergeyeva,Gerald Schulman,George Ting,Mark Unruh,Robert A. Star,Alan S. Kliger +23 more
TL;DR: Frequent hemodialysis, as compared with conventional hemodIALysis, was associated with favorable results with respect to the composite outcomes of death or change in left ventricular mass and death orchange in a physical-health composite score but prompted more frequent interventions related to vascular access.
Journal ArticleDOI
Effect of frequent nocturnal hemodialysis vs conventional hemodialysis on left ventricular mass and quality of life: a randomized controlled trial.
Bruce F. Culleton,Michael Walsh,Scott Klarenbach,Garth Mortis,Narine Scott-Douglas,Robert R. Quinn,Marcello Tonelli,Sarah Donnelly,Matthias G. Friedrich,Andreas Kumar,Houman Mahallati,Brenda R. Hemmelgarn,Braden J. Manns +12 more
TL;DR: This preliminary study revealed that frequent nocturnal hemodialysis improved left ventricular mass, reduced the need for blood pressure medications, improved some measures of mineral metabolism, and improved selected measures of quality of life.
Journal ArticleDOI
The effects of frequent nocturnal home hemodialysis: the Frequent Hemodialysis Network Nocturnal Trial
Michael V. Rocco,Robert S. Lockridge,Gerald J. Beck,Paul W. Eggers,Jennifer J. Gassman,Tom Greene,Brett Larive,Christopher T. Chan,Glenn M. Chertow,Glenn M. Chertow,Michael Copland,Christopher D. Hoy,Robert M. Lindsay,Nathan W. Levin,Daniel B. Ornt,Andreas Pierratos,Mary Pipkin,Sanjay Rajagopalan,John B. Stokes,Mark Unruh,Robert A. Star,Alan S. Kliger +21 more
TL;DR: Patients in the nocturnal arm had improved control of hyperphosphatemia and hypertension, but no significant benefit among the other main secondary outcomes.
Journal ArticleDOI
Rapid Fluid Removal During Dialysis Is Associated With Cardiovascular Morbidity and Mortality
TL;DR: Higher ultrafiltration rates in hemodialysis patients are associated with a greater risk of all-cause and cardiovascular death, and hospitalization for cardiovascular disease.
Journal ArticleDOI
Guidelines for the management of chronic kidney disease
Adeera Levin,Brenda R. Hemmelgarn,Bruce F. Culleton,Sheldon W. Tobe,Philip A. McFarlane,Marcel Ruzicka,Kevin D. Burns,Braden J. Manns,Colin T. White,Francoise Madore,Louise Moist,Scott Klarenbach,Brendan J. Barrett,Robert N. Foley,Kailash Jindal,Peter A. Senior,Neesh Pannu,Sabin Shurraw,Ayub Akbari,Adam Cohn,Martina Reslerova,Vinay Deved,David C. Mendelssohn,Gihad Nesrallah,Joanne Kappel,Marcello Tonelli +25 more
TL;DR: New guidelines for the management of chronic kidney disease have been developed by the Canadian Society of Nephrology and describe key aspects of the management.
References
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A sharper Bonferroni procedure for multiple tests of significance
TL;DR: In this article, a simple procedure for multiple tests of significance based on individual p-values is derived, which is sharper than Holm's (1979) sequentially rejective procedure.
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Users' Guides to the Medical Literature
Gordon H. Guyatt,Drummond Rennie +1 more
TL;DR: Without a way of critically appraising the information they receive, clinicians are relatively helpless in deciding what new information to learn and decide how to modify their practice.
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The RAND-36 measure of health-related quality of life
Ron D. Hays,Leo S. Morales +1 more
TL;DR: This paper provides example applications of the RAND-36 cross-sectionally and longitudinally, provides information on what a clinically important difference is for the Rand-36 scales, and provides guidance for summarizing theRand-36 in a single number.
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Determining Clinically Important Differences in Health Status Measures
Gregory P. Samsa,David Edelman,David Edelman,Margaret Rothman,G R Williams,Joseph Lipscomb,David B. Matchar,David B. Matchar +7 more
TL;DR: A literature review and pilot study suggest that effect size-based CID benchmarks are similar to those which would be obtained using more traditional methods, and suggest that the use of standardised effect size benchmarks has a number of advantages.
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Projecting the Number of Patients with End-Stage Renal Disease in the United States to the Year 2015
David T. Gilbertson,Jiannong Liu,Jay L. Xue,Thomas A. Louis,Craig A. Solid,James P. Ebben,Allan J. Collins +6 more
TL;DR: A Markov model developed to predict ESRD incidence, prevalence, and mortality to the year 2015 is discussed, incorporating expected changes in age/race distributions, diabetes prevalence, ESRd incidence, and probability of death.
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In-center hemodialysis six times per week versus three times per week.
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The effects of frequent nocturnal home hemodialysis: the Frequent Hemodialysis Network Nocturnal Trial
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