Frog Virus 3 DNA Replication Occurs in Two Stages
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Cites background from "Frog Virus 3 DNA Replication Occurs..."
...Following its translation in the cytoplasm, the viral DNA polymerase enters the nucleus where it synthesizes unit to twice unit size copies of the viral genome, representing first stage DNA synthesis (Goorha, 1982; Goorha et al., 1978)....
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...In contrast, fish infected with megalocytiviruses are lethargic, have abnormal coloration of the body, petechia of the gills, and lesions involving the spleen, gills, and digestive tract (Gibson-Kueh et al., 2003; He et al., 2000; Jung et al., 1997)....
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...ADVANCES IN VIRUS RESEARCH, VOL 65...
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Cites background from "Frog Virus 3 DNA Replication Occurs..."
...First-Stage Viral DNA Replication Following synthesis of the viral DNA polymerase and its subsequent translocation into the nucleus, viral DNA replication commences within the nucleus and results in the synthesis of genome-size to twice genome-size DNA molecules (Goorha 1982)....
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...Second-Stage Viral DNA Replication: Concatamer Formation In addition to methylation, viral DNA undergoes a second round of DNA synthesis, which results in the formation of large, concatameric structures that are more than ten times larger than genome-sized units (Goorha 1982)....
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...In addition to methylation, viral DNA undergoes a second round of DNA synthesis, which results in the formation of large, concatameric structures that are more than ten times larger than genome-sized units (Goorha 1982)....
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...Following synthesis of the viral DNA polymerase and its subsequent translocation into the nucleus, viral DNA replication commences within the nucleus and results in the synthesis of genome-size to twice genome-size DNA molecules (Goorha 1982)....
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215 citations