FTY720 modulates human oligodendrocyte progenitor process extension and survival.
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Cites background or methods from "FTY720 modulates human oligodendroc..."
...Human foetal OPCs were isolated as previously described (Miron et al., 2008)....
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...Our previous studies have characterized the purity of these cultures (Miron et al., 2007, 2008)....
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685 citations
Cites background from "FTY720 modulates human oligodendroc..."
...These effects could alter the myelination or remyelination processes.(59)...
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...S1P5 and the S1P1 are both expressed on oligodendrocytes, and their relative levels of expression seem to depend on the developmental stages of the cell.(59,96) Activation of S1P receptor subtypes initiates distinct intracellular signaling pathways that can produce opposing effects....
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...1).29,35,38Y40,61,62,64,70 Fingolimod exerts its therapeutic effects through modulation of S1P receptors by fingolimod-phosphate and may well achieve its beneficial effects in patients with MS through receptor-mediated actions both on the immune system and in the CNS.4,39,46,59,70 Role of S1P Receptors in Lymphocyte Recirculation Sphingosine 1-phosphate and S1P receptors play important roles in normal immune function....
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...Fingolimod exposure in vitro has also been reported to increase the number of both progenitor and mature oligodendrocytes, to protect oligodendrocytes from cell death induced by cytokines or the withdrawal of growth factors, and to modulate process outgrowth (both retraction and extension).(59,101,102) The effects of fingolimod on human oligodendrocytes and process extension/retraction were found to be time, dose, and stage dependent, which may in part reflect the relative levels of expression of the relevant receptors....
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...Patterns of expression of S1P receptors can change with the activation and functional status of cells.(59,60) Sphingosine 1-phosphate receptors are involved in multiple biological processes, including leukocyte recirculation, neural cell proliferation, morphological changes, migration, endothelial cell function, vasoregulation, and cardiovascular development, as summarized in Table 1....
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References
1,641 citations
"FTY720 modulates human oligodendroc..." refers background in this paper
...FTY720 is an agonist of four of five known G-protein–coupled receptors, termed S1P1, 3, 4, and 5, that are part of the endothelial differentiation gene-related (Edg) family.(12,13) Edg receptor messenger RNA (mRNA) levels are upregulated around the perimeter of MS brain lesions....
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1,025 citations
"FTY720 modulates human oligodendroc..." refers background in this paper
...FTY720, a lipophilic sphingosine-1-phosphate (S1P) analogue that crosses the blood–brain barrier,(10) is being evaluated as a potential therapy for MS because of its antiinflammatory properties.(11) FTY720 is an agonist of four of five known G-protein–coupled receptors, termed S1P1, 3, 4, and 5, that are part of the endothelial differentiation gene-related (Edg) family....
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800 citations
"FTY720 modulates human oligodendroc..." refers background in this paper
...Results from experimental models of central nervous system (CNS) demyelination indicate that remyelination is dependent on oligodendrocyte progenitor cells (OPCs) rather than on previously myelinating oligodendrocytes.(3,4) Myelin lineage progenitor cells have been identified in both the normal adult human CNS and in MS lesions....
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684 citations
658 citations
"FTY720 modulates human oligodendroc..." refers methods in this paper
...Actin transcript levels were used as endogenous controls for the amount of RNA transcribed, and primers/ probes were designed using the PRIMER express software.(32) All S1P receptor levels were normalized to the actin levels in the corresponding sample....
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