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Journal ArticleDOI

Fully room temperature and label free biosensing based on an ink-jet printed polymer microdisk laser

01 Mar 2021-Optical Materials Express (The Optical Society)-Vol. 11, Iss: 3, pp 592-602
TL;DR: In this article, a microdisk laser was fabricated using a low-viscosity hyper branched polymer FC-V-50 using ink-jet printing, and was surface modified at room temperature within a relatively short time compared to conventional methods.
Abstract: Materials with biomolecule-compatible functional groups are desirable for the fabrication of microdisk lasers used in bio-sensing applications. In this study, a microdisk laser was fabricated using a low-viscosity hyper branched polymer FC-V-50 using ink-jet printing, and was surface-modified at room temperature within a relatively short time compared to conventional methods. The carboxyl functional group of the FC-V-50 polymer was used for surface modification and biotinylation. The adsorption characteristics of the microdisk laser were evaluated using bovine serum albumin, avidin, and streptavidin. This study reports the first demonstration of label-free biosensing using the FC-V-50 polymer-based microdisk laser.
Citations
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Journal ArticleDOI
01 Mar 2022-Polymers
TL;DR: In this paper , a review summarizes the deposition principles and control parameters of each deposition method for pentacene and its derivatives, and also provides a comparison of each method to provide recommendations for specific device applications.
Abstract: Pentacene is a well-known conjugated organic molecule with high mobility and a sensitive photo response. It is widely used in electronic devices, such as in organic thin-film transistors (OTFTs), organic light-emitting diodes (OLEDs), photodetectors, and smart sensors. With the development of flexible and wearable electronics, the deposition of good-quality pentacene films in large-scale organic electronics at the industrial level has drawn more research attention. Several methods are used to deposit pentacene thin films. The thermal evaporation technique is the most frequently used method for depositing thin films, as it has low contamination rates and a well-controlled deposition rate. Solution-processable methods such as spin coating, dip coating, and inkjet printing have also been widely studied because they enable large-scale deposition and low-cost fabrication of devices. This review summarizes the deposition principles and control parameters of each deposition method for pentacene and its derivatives. Each method is discussed in terms of experimentation and theory. Based on film quality and device performance, the review also provides a comparison of each method to provide recommendations for specific device applications.

7 citations

Journal ArticleDOI
TL;DR: A hybrid plasmonic transducer made of a Poly‐(ethylene glycol) diacrylate (PEGDA) hydrogel and citrate gold nanoparticles detects the biotin‐streptavidin interaction at picomolar concentration.
Abstract: A hybrid plasmonic transducer made of a Poly‐(ethylene glycol) diacrylate (PEGDA) hydrogel and citrate gold nanoparticles detects the biotin‐streptavidin interaction at picomolar (× 10−12 m ) concentrations. The all‐solution fabrication strategy, herein proposed, is large‐scale, easily tunable, and low‐cost; nevertheless, this innovative device is highly reproducible and optically stable, and it can be used in dual‐optical mode. Indeed, both metal‐enhanced fluorescence and localized surface plasmon resonance signals can be exploited to quantify the biorecognition process in a 3D architecture. The large swelling capability of high molecular weight PEGDA is used to investigate the plasmon absorption variations resulting from the exposure to biological solutions containing high molecular weight molecules within the 3D network. The proposed transducer represents a low‐cost, flexible, and easy‐to‐use platform for sensing applications in biomedical or environmental diagnostics.

5 citations

Journal ArticleDOI
Yuya Mikami1, Hiroaki Yoshioka1, Nasim Obata1, Sangmin Han1, Yuji Oki1 
TL;DR: In this article, a hybrid simulation method that combines electromagnetic field analysis and ray tracing based on wave optics and ray optics is proposed to estimate the refractive index of nanoporous materials by combining numerical simulations and experiments.
Abstract: In this study, we demonstrated an accurate estimation of the refractive index in nanoporous structures using a novel hybrid simulation method that combines electromagnetic field analysis and ray tracing based on wave optics and ray optics. A novel theoretical model for the refractive index in a nanoporous structure was developed using a simulation of the effective medium approximation (EMA) and screening effect with consideration of polarization dependence. The optical properties were then experimentally evaluated on aggregates of silica nanoparticles. Based on the measured properties, nanoparticles were predicted to have sufficient transparency for the optical cavity. A nanoporous microdisk laser was thus fabricated with laser dye to demonstrate that the nanoporous microdisk was capable of lasing. The microdisk functioned sufficiently as an optical cavity and had well-matched characteristics. This study provides a novel viewpoint of polarization dependence to estimate the refractive index of nanoporous materials by combining numerical simulations and experiments.

2 citations

References
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Journal ArticleDOI
TL;DR: Inkjet printing has been used as a free-form fabrication method for building three-dimensional parts and is being explored as a way of printing electrical and optical devices, especially where these involve organic components.
Abstract: Inkjet printing is familiar as a method of printing text and images onto porous surfaces. In the last few years it has been used as a free-form fabrication method for building three-dimensional parts and is being explored as a way of printing electrical and optical devices, especially where these involve organic components. Inkjet printers are also being used to produce arrays of proteins and nucleic acids. The need for a versatile inkjet technology for free-forming materials and for multilayer devices raises a number of materials problems that do not apply to conventional printing of images. Higher resolutions will be needed if organic transistors are to be printed. Also, it must be possible to print pinhole-free layers to avoid shorting of devices. Multiple layers must be printed such that they mix and react to form a single material or such that they form discrete unmixed layers. Printing on dense rather than porous substrates will be the norm. This article reviews the range of materials that has been ...

1,774 citations

Journal ArticleDOI
TL;DR: The enhancement mechanisms responsible for the extreme sensitivity of the WGM biosensor are described, its current implementations and applications are reviewed, and its future possibilities are discussed.
Abstract: Optical label-free detectors, such as the venerable surface plasmon resonance (SPR) sensor, are generally favored for their ability to obtain quantitative data on intermolecular binding. However, before the recent introduction of resonant microcavities that use whispering gallery mode (WGM) recirculation, sensitivity to single binding events had not materialized. Here we describe the enhancement mechanisms responsible for the extreme sensitivity of the WGM biosensor, review its current implementations and applications, and discuss its future possibilities.

1,621 citations

Journal ArticleDOI
TL;DR: This work proposes a label-free biosensor based on microring cavities in Silicon-on-Insulator (SOI) that fits in an area below 10x10mum(2), and uses the avidin/biotin high affinity couple to demonstrate good repeatability and detection of protein concentrations down to 10ng/ml.
Abstract: Label-free biosensors attempt to overcome the stability and reliability problems of biosensors relying on the detection of labeled molecules We propose a label-free biosensor based on microring cavities in Silicon-on-Insulator (SOI) that fits in an area below 10x10mum(2) The resonance wavelength shift that occurs when the surroundings of a cavity is changed, is used for sensing While theoretically the performance for bulk refractive index changes is moderate (10(-5)), this device performs outstanding in terms of absolute molecular mass sensing (theoretical sensitivity of 1fg molecular mass) thanks to its extremely small dimensions We use the avidin/biotin high affinity couple to demonstrate good repeatability and detection of protein concentrations down to 10ng/ml Fabrication with Deep UV lithography allows for cheap mass production and integration with electronic functions for complete lab-on-chip devices

809 citations

Journal ArticleDOI
TL;DR: The theoretical shift for adsorption of a single protein is found to be extremely sensitive to the target region, with adsor adaptation in the most sensitive region varying as 1/R(5/2).
Abstract: Biosensors based on the shift of whispering-gallery modes in microspheres accompanying protein adsorption are described by use of a perturbation theory. For random spatial adsorption, theory predicts that the shift should be inversely proportional to micorsphere radius R and proportional to protein surface density and excess polarizability. Measurements are found to be consistent with the theory, and the correspondence enables the average surface area occupied by a single protein to be estimated. These results are consistent with crystallographic data for bovine serum albumin. The theoretical shift for adsorption of a single protein is found to be extremely sensitive to the target region, with adsorption in the most sensitive region varying as 1R 52 . Specific parameters for single protein or virus particle detection are predicted. © 2003 Optical

770 citations

Journal ArticleDOI
Janos Vörös1
TL;DR: It is indicated that water and solvent molecules not only influence the 3D structure of proteins in solution but also play a crucial role in their adsorption onto surfaces.

720 citations