Fulvestrant ('Faslodex')--a new treatment option for patients progressing on prior endocrine therapy.
Citations
158 citations
146 citations
Cites background from "Fulvestrant ('Faslodex')--a new tre..."
...estrogen receptor modulators (SERMs) such as arzoxifene, with more favorable tissue-specific ER effects than tamoxifen [59], as well as selective ER downregulators (SERDs) such as the potent antiestrogen fulvestrant (Faslodex, ICI 182,780), which target and degrade the ER [60, 71], are already in clinical use or at the final stages of clinical development....
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143 citations
101 citations
Cites background from "Fulvestrant ('Faslodex')--a new tre..."
...These tumours often remain ERa positive and may respond to an alternative endocrine agent, showing ERa-dependence for the continued growth of these tumours (Buzdar and Howell, 2001; Morris and Wakeling, 2002), and indicating altered ERa function as a possible mechanism underlying treatment failure....
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...…tumours often remain ERα positive and may respond to an alternative endocrine agent, demonstrating ERα-dependence for the continued growth of these tumours (Buzdar and Howell, 2001; Morris and Wakeling, 2002), and indicating altered ERα function as a possible mechanism underlying treatment failure....
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98 citations
References
60 citations
"Fulvestrant ('Faslodex')--a new tre..." refers background in this paper
...Fulvestrant also produced involution of the uterus, similar to that seen following estrogen withdrawal (Dukes et al. 1992)....
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56 citations
"Fulvestrant ('Faslodex')--a new tre..." refers background in this paper
...Selective estrogen receptor modulators Toremifene (Hayes et al. 1995), raloxifene (Thiebaud & Secrest 2001), idoxifene (Dowsett et al. 2000), and droloxifene (Rauschning & Pritchard 1994) are all antiestrogens that, like tamoxifen, compete with estrogen for the ER and have been collectively termed…...
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...1995), raloxifene (Thiebaud & Secrest 2001), idoxifene (Dowsett et al. 2000), and droloxifene (Rauschning & Pritchard 1994) are all antiestrogens that, like tamoxifen, compete with estrogen for the ER and have been collectively termed SERMs....
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52 citations
"Fulvestrant ('Faslodex')--a new tre..." refers background in this paper
...Moreover, due to their similar modes of action, patients who have previously been treated with tamoxifen are likely to have developed cross-resistance to these agents (Lee et al. 2000)....
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50 citations
"Fulvestrant ('Faslodex')--a new tre..." refers background in this paper
...Although important for normal physiological growth processes, estrogens are also known to play a significant role in the stimulation and growth of breast tumors (Hulka 1996)....
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45 citations