Functional analysis of cancer-associated EGFR mutants using a cellular assay with YFP-tagged EGFR intracellular domain
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Cites background from "Functional analysis of cancer-assoc..."
...Although the most common EGFR mutations are the 15-bp ELREA deletion in exon 19 and the L858R substitution in exon 21 [2,3], other less frequent deletions have been identified [4,6,8,23]....
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Additional excerpts
...functionally silent polymorphism [28] (Table 2)....
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References
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"Functional analysis of cancer-assoc..." refers background in this paper
...Subsequently, the analysis of EGFR gene sequence revealed the presence of somatic mutations in the kinase domain of the receptor in most responding patients [4-6]....
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...The functional characteristics of the two most common types of EGFR alterations, the exon 19 deletions and the L858R point mutation, have been studied in detail using biochemical assays, cell-based systems and mouse models [4-6], [9-14]....
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...First, by using a fragment of the receptor lacking the extracellular domain one would expect to reduce interference from the experimental context, which may have been partially responsible for some controversial findings [4,6,10,19,20]....
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9,265 citations
4,071 citations
"Functional analysis of cancer-assoc..." refers background in this paper
...Subsequently, the analysis of EGFR gene sequence revealed the presence of somatic mutations in the kinase domain of the receptor in most responding patients [4-6]....
[...]
...The functional characteristics of the two most common types of EGFR alterations, the exon 19 deletions and the L858R point mutation, have been studied in detail using biochemical assays, cell-based systems and mouse models [4-6], [9-14]....
[...]
...First, by using a fragment of the receptor lacking the extracellular domain one would expect to reduce interference from the experimental context, which may have been partially responsible for some controversial findings [4,6,10,19,20]....
[...]
3,812 citations
3,390 citations