Journal ArticleDOI
Functional connectivity in the motor cortex of resting human brain using echo-planar MRI.
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TLDR
It is concluded that correlation of low frequency fluctuations, which may arise from fluctuations in blood oxygenation or flow, is a manifestation of functional connectivity of the brain.Abstract:
An MRI time course of 512 echo-planar images (EPI) in resting human brain obtained every 250 ms reveals fluctuations in signal intensity in each pixel that have a physiologic origin. Regions of the sensorimotor cortex that were activated secondary to hand movement were identified using functional MRI methodology (FMRI). Time courses of low frequency (< 0.1 Hz) fluctuations in resting brain were observed to have a high degree of temporal correlation (P < 10(-3)) within these regions and also with time courses in several other regions that can be associated with motor function. It is concluded that correlation of low frequency fluctuations, which may arise from fluctuations in blood oxygenation or flow, is a manifestation of functional connectivity of the brain.read more
Citations
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Journal ArticleDOI
Advances in functional and structural MR image analysis and implementation as FSL.
Stephen M. Smith,Mark Jenkinson,Mark W. Woolrich,Mark W. Woolrich,Christian F. Beckmann,Behrens Tej.,Heidi Johansen-Berg,Peter R. Bannister,M De Luca,Ivana Drobnjak,D E Flitney,Rami K. Niazy,J Saunders,J Vickers,Yongyue Zhang,N. De Stefano,J M Brady,Paul M. Matthews +17 more
TL;DR: A review of the research carried out by the Analysis Group at the Oxford Centre for Functional MRI of the Brain (FMRIB) on the development of new methodologies for the analysis of both structural and functional magnetic resonance imaging data.
Journal ArticleDOI
The Brain's Default Network Anatomy, Function, and Relevance to Disease
TL;DR: Past observations are synthesized to provide strong evidence that the default network is a specific, anatomically defined brain system preferentially active when individuals are not focused on the external environment, and for understanding mental disorders including autism, schizophrenia, and Alzheimer's disease.
Journal ArticleDOI
The human brain is intrinsically organized into dynamic, anticorrelated functional networks
Michael D. Fox,Abraham Z. Snyder,Justin L. Vincent,Maurizio Corbetta,David C. Van Essen,Marcus E. Raichle +5 more
TL;DR: It is suggested that both task-driven neuronal responses and behavior are reflections of this dynamic, ongoing, functional organization of the brain, featuring the presence of anticorrelated networks in the absence of overt task performance.
Journal ArticleDOI
The organization of the human cerebral cortex estimated by intrinsic functional connectivity
B.T. Thomas Yeo,Fenna M. Krienen,Jorge Sepulcre,Jorge Sepulcre,Mert R. Sabuncu,Mert R. Sabuncu,Danial Lashkari,Marisa O. Hollinshead,Marisa O. Hollinshead,Joshua L. Roffman,Jordan W. Smoller,Lilla Zöllei,Jonathan R. Polimeni,Bruce Fischl,Bruce Fischl,Hesheng Liu,Randy L. Buckner +16 more
TL;DR: In this paper, the organization of networks in the human cerebrum was explored using resting-state functional connectivity MRI data from 1,000 subjects and a clustering approach was employed to identify and replicate networks of functionally coupled regions across the cerebral cortex.
Journal ArticleDOI
Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging.
Michael D. Fox,Marcus E. Raichle +1 more
TL;DR: Recent studies examining spontaneous fluctuations in the blood oxygen level dependent (BOLD) signal of functional magnetic resonance imaging as a potentially important and revealing manifestation of spontaneous neuronal activity are reviewed.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Stephen M. Rao,Jeffrey R. Binder,Peter A. Bandettini,Thomas A. Hammeke,F Z Yetkin,Andrzej Jesmanowicz,L. M. Lisk,George L. Morris,Wade M. Mueller,L. D. Estkowski,E. G. Wong,Victor M. Haughton,James S. Hyde +12 more
TL;DR: Six right-handed healthy subjects were scanned while they performed self-paced simple and complex finger movements with the right and left hands, and preliminary results are consistent with hierarchical models of voluntary motor control.
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