Functional role of type I and type II interferons in antiviral defense.
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Cites background from "Functional role of type I and type ..."
...fend against a broad spectrum of pathogens [60, 61]....
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...Although both types of IFN are crucial in the immediate cellular response to viral infection, the immunomodulatory activities of IFN- (discussed elsewhere) become important later in the response in coordinating the immune response and establishing an antiviral state for longer term control [54, 60, 328, 329]....
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Cites background from "Functional role of type I and type ..."
...IFN- plays a major immunomodulatory role and is a key mediator of virus-specific cellular immunity (176, 187, 290)....
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...IFN- / receptor-deficient mutant animals are highly susceptible to infection by an array of different viruses exemplified by members of the Poxviridae (vaccinia virus), Arenaviridae (lymphocytic choriomeningitis virus), Rhabdoviridae (vesicular stomatitis virus [VSV]), and Togaviridae (Sindbis virus, Semliki Forest virus, and Venezuelan equine encephalitis virus) despite the presence of an otherwise intact immune system and a normal resistance to the microbial pathogen Listeria monocytogenes (128, 146, 177, 290, 345, 416)....
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...By contrast, IFN- receptor-deficient mice in which either the IFNGR-1 or IFNGR-2 gene has been disrupted are greatly impaired in their ability to resist a variety of microbial pathogens and some viral pathogens including vaccinia virus and herpes simplex virus (10, 48, 176, 244, 290)....
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Cites background from "Functional role of type I and type ..."
...Accordingly, IFNAR-deficient mice have increased susceptibility to numerous viruses but maintain resistance to other microbial pathogens, such as Listeria monocytogenes...
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References
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