Journal ArticleDOI
G proteins and dual control of adenylate cyclase
Reads0
Chats0
TLDR
It is clear that detailed understanding of the mechanism of regulation of CAMP synthesis will soon be achieved from study of the interactions of purified components that have been reconstituted in lipid bilayers of defined composition.About:
This article is published in Cell.The article was published on 1984-03-01. It has received 1645 citations till now. The article focuses on the topics: G protein & Cyclase activity.read more
Citations
More filters
Journal ArticleDOI
Inositol trisphosphate, a novel second messenger in cellular signal transduction.
TL;DR: Diacylglycerol operates within the plane of the membrane to activate protein kinase C, whereas inositol trisphosphate is released into the cytoplasm to function as a second messenger for mobilizing intracellular calcium.
Journal ArticleDOI
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
TL;DR: The cloning and expression of a complementary DNA that encodes a G protein-coupled receptor that is involved in cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana are suggested.
Journal ArticleDOI
Diversity of G proteins in signal transduction.
TL;DR: The heterotrimeric guanine nucleotide-binding proteins acting as switches that regulate information processing circuits connecting cell surface receptors to a variety of effectors generate the pathways that modulate cellular responses to complex chemical signals.
Journal ArticleDOI
Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal
TL;DR: An antiserum against purified cholinergic synaptic vesicles from Torpedo and expression screening was used to isolate a cDNA clone encoding synuclein, a 143 amino acid neuron-specific protein that is expressed only in nervous system tissue.
Journal ArticleDOI
Identification of a family of muscarinic acetylcholine receptor genes
TL;DR: Analysis of human and rat genomic clones indicates that there are at least four functional muscarinic receptor genes and that these genes lack introns in the coding sequence.